VEGFA


Summary: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
vascular endothelial growth factor AMIM:192240Ensembl:ENSG00000112715HGNC:HGNC:12680PA373026p21.1

GO terms in VEGFA


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0001968fibronectin binding
MFIDAGO:0005125cytokine activity
MFISSGO:0005125cytokine activity
MFIPIGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005172vascular endothelial growth factor receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIDAGO:0008083growth factor activity
MFISSGO:0008083growth factor activity
MFIDAGO:0008201heparin binding
MFIMPGO:0008201heparin binding
MFIBAGO:0042056chemoattractant activity
MFIDAGO:0042056chemoattractant activity
MFIPIGO:0042802identical protein binding
MFISSGO:0042803protein homodimerization activity
MFIBAGO:0043183vascular endothelial growth factor receptor 1 binding
MFIPIGO:0043183vascular endothelial growth factor receptor 1 binding
MFIBAGO:0043184vascular endothelial growth factor receptor 2 binding
MFIPIGO:0043184vascular endothelial growth factor receptor 2 binding
MFIBAGO:0043185vascular endothelial growth factor receptor 3 binding
MFIDAGO:0046982protein heterodimerization activity
MFIPIGO:0048018receptor ligand activity
MFICGO:0050840extracellular matrix binding
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCISSGO:0005615extracellular space
CCIDAGO:0005737cytoplasm
CCIDAGO:0009986cell surface
CCIEAGO:0016020membrane
CCIDAGO:0030141secretory granule
CCNASGO:0031012extracellular matrix
CCTASGO:0031093platelet alpha granule lumen
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0001525angiogenesis
BPIDAGO:0001525angiogenesis
BPISSGO:0001541ovarian follicle development
BPISSGO:0001569branching involved in blood vessel morphogenesis
BPTASGO:0001570vasculogenesis
BPIBAGO:0001666response to hypoxia
BPIDAGO:0001666response to hypoxia
BPISSGO:0001701in utero embryonic development
BPISSGO:0001822kidney development
BPIBAGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIBAGO:0001938positive regulation of endothelial cell proliferation
BPIDAGO:0001938positive regulation of endothelial cell proliferation
BPISSGO:0001938positive regulation of endothelial cell proliferation
BPIBAGO:0002040sprouting angiogenesis
BPIDAGO:0002042cell migration involved in sprouting angiogenesis
BPISSGO:0002052positive regulation of neuroblast proliferation
BPISSGO:0002053positive regulation of mesenchymal cell proliferation
BPIDAGO:0002092positive regulation of receptor internalization
BPTASGO:0002576platelet degranulation
BPTASGO:0002687positive regulation of leukocyte migration
BPISSGO:0003007heart morphogenesis
BPISSGO:0003151outflow tract morphogenesis
BPISSGO:0003169coronary vein morphogenesis
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0007399nervous system development
BPISSGO:0007498mesoderm development
BPISSGO:0007595lactation
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIDAGO:0008360regulation of cell shape
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPTASGO:0019221cytokine-mediated signaling pathway
BPIDAGO:0030224monocyte differentiation
BPIDAGO:0030225macrophage differentiation
BPISSGO:0030324lung development
BPIDAGO:0030335positive regulation of cell migration
BPISSGO:0030855epithelial cell differentiation
BPIDAGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPISSGO:0031077post-embryonic camera-type eye development
BPIDAGO:0031334positive regulation of protein complex assembly
BPIDAGO:0031954positive regulation of protein autophosphorylation
BPIDAGO:0032147activation of protein kinase activity
BPIDAGO:0032793positive regulation of CREB transcription factor activity
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0035148tube formation
BPIDAGO:0035767endothelial cell chemotaxis
BPIDAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPISSGO:0036303lymph vessel morphogenesis
BPIDAGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
BPIBAGO:0038084vascular endothelial growth factor signaling pathway
BPIDAGO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
BPISSGO:0038190VEGF-activated neuropilin signaling pathway
BPISSGO:0042462eye photoreceptor cell development
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIMPGO:0043066negative regulation of apoptotic process
BPISSGO:0043129surfactant homeostasis
BPIDAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIDAGO:0043536positive regulation of blood vessel endothelial cell migration
BPIBAGO:0045766positive regulation of angiogenesis
BPIDAGO:0045766positive regulation of angiogenesis
BPIMPGO:0045766positive regulation of angiogenesis
BPIDAGO:0045785positive regulation of cell adhesion
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIDAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPISSGO:0048469cell maturation
BPISSGO:0048593camera-type eye morphogenesis
BPISSGO:0048739cardiac muscle fiber development
BPISSGO:0048754branching morphogenesis of an epithelial tube
BPISSGO:0048842positive regulation of axon extension involved in axon guidance
BPISSGO:0048844artery morphogenesis
BPISSGO:0050679positive regulation of epithelial cell proliferation
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0050918positive chemotaxis
BPIDAGO:0050927positive regulation of positive chemotaxis
BPIBAGO:0050930induction of positive chemotaxis
BPNASGO:0050930induction of positive chemotaxis
BPIDAGO:0051272positive regulation of cellular component movement
BPIEAGO:0051781positive regulation of cell division
BPIDAGO:0051894positive regulation of focal adhesion assembly
BPISSGO:0060319primitive erythrocyte differentiation
BPISSGO:0060749mammary gland alveolus development
BPIBAGO:0060754positive regulation of mast cell chemotaxis
BPISSGO:0060948cardiac vascular smooth muscle cell development
BPISSGO:0060982coronary artery morphogenesis
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPIMPGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPIDAGO:0071456cellular response to hypoxia
BPISSGO:0071542dopaminergic neuron differentiation
BPISSGO:0071679commissural neuron axon guidance
BPIDAGO:0090037positive regulation of protein kinase C signaling
BPIDAGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIGIGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIMPGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPISSGO:0090190positive regulation of branching involved in ureteric bud morphogenesis
BPISSGO:0090259regulation of retinal ganglion cell axon guidance
BPISSGO:0097475motor neuron migration
BPIDAGO:0097533cellular stress response to acid chemical
BPIDAGO:1900086positive regulation of peptidyl-tyrosine autophosphorylation
BPIDAGO:1900745positive regulation of p38MAPK cascade
BPIDAGO:1901727positive regulation of histone deacetylase activity
BPISSGO:1902336positive regulation of retinal ganglion cell axon guidance
BPIDAGO:1903572positive regulation of protein kinase D signaling
BPIGIGO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPIDAGO:1903672positive regulation of sprouting angiogenesis
BPIGIGO:1903672positive regulation of sprouting angiogenesis

Gene expression in normal tissue: VEGFA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VEGFA


DatabasePathway IDPathway Des.
wikipathwaysWP1591Heart Development
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2435Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2727Regulation of Hypoxia-inducible Factor (HIF) by oxygen
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP3593miR-148a-miR-31-FIH1-HIF1?-Notch signaling in glioblastoma
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP3678Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3943Robo4 and VEGF Signaling Pathways Crosstalk
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4086Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4206Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP516Hypertrophy Model
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
smpdbSMP00420Bevacizumab Action Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidglypican_1pathwayGlypican 1 network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidhif2pathwayHIF-2-alpha transcription factor network
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidplexind1_pathwayPlexin-D1 Signaling
pids1p_s1p1_pathwayS1P1 pathway
pids1p_s1p3_pathwayS1P3 pathway
pidshp2_pathwaySHP2 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
pidvegf_vegfr_pathwayVEGF and VEGFR signaling network
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
biocartahifpathwayhypoxia-inducible factor in the cardivascular system
biocartano1pathwayactions of nitric oxide in the heart
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1234158Regulation of gene expression by Hypoxia-inducible Factor
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194313VEGF ligand-receptor interactions
reactomeR-HSA-195399VEGF binds to VEGFR leading to receptor dimerization
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
reactomeR-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD21Fluorouracil1
iGMDRD152179324-69-71
iGMDRD259EX-5271
iGMDRD795BMN 6731
iGMDRD889Compound 7d-cis3
iGMDRD387CHIR-990212
iGMDRD659Avagacestat (BMS-708163)1
iGMDRD654SL 0101-12
iGMDRD135Lenalidomide1
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD781Sirolimus3
iGMDRD577BIX012943
iGMDRD312Pelitinib1
iGMDRD453GW25801
iGMDRD399Selumetinib2
iGMDRD451Serdemetan3
iGMDRD700AUY9221
iGMDRD134Sorafenib1
iGMDRD474Avrainvillamide3
iGMDRD318PAC-13
iGMDRD1019TL-2-1051
iGMDRD178MG-1321
iGMDRD461VX-11e1
iGMDRD605AZD64821
iGMDRD347Y-399831
iGMDRD719IOX22
iGMDRD148Pifithrin-mu3
iGMDRD48Dexamethasone3
iGMDRD20Embelin1
iGMDRD125BIRB-7961
iGMDRD532Olaparib1
iGMDRD122Levoleucovorin1
iGMDRD329Merck601
iGMDRD80Irinotecan1
iGMDRD544Vismodegib (GDC-0449)1
iGMDRD993QL-XII-611
iGMDRD837Bevacizumab1
iGMDRD695FR-1802041
iGMDRD412VX-7021
iGMDRD353PD03259011
iGMDRD935JQ121
iGMDRD227Fatostatin A6
iGMDRD293Bleomycin2
iGMDRD311Dacinostat1
iGMDRD733SGC09461
iGMDRD372TGX 2211
iGMDRD434BMS-5369241

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VEGFA

​​​​