EPHB6
Summary: This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor B6 | MIM:602757 | Ensembl:ENSG00000106123 | HGNC:HGNC:3396 | PA27828 | 7q34 |
GO terms in EPHB6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005003 | ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: EPHB6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD137 | Indisulam | 7 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD560 | MK-2206 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB6
CLASSFICATION
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