EPHB6


Summary: This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor B6MIM:602757Ensembl:ENSG00000106123HGNC:HGNC:3396PA278287q34

GO terms in EPHB6


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIBAGO:0043005neuron projection
CCIBAGO:0043235receptor complex
BPIBAGO:0007275multicellular organism development
BPIBAGO:0009968negative regulation of signal transduction
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPTASGO:0048013ephrin receptor signaling pathway
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
MFIBAGO:0004709MAP kinase kinase kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIEAGO:0005003ephrin receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFTASGO:0038023signaling receptor activity

Gene expression in normal tissue: EPHB6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHB6


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD577BIX012944
iGMDRD888Compound 441
iGMDRD398Sepantronium4
iGMDRD562Navitoclax5
iGMDRD100Zebularine2
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate3
iGMDRD52Rotenone2
iGMDRD8024-methylfasudil1
iGMDRD270Ciclosporin2
iGMDRD394BX-7952
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside2
iGMDRD201SKI II2
iGMDRD484Pluripotin2
iGMDRD427ABT7376
iGMDRD889Compound 7d-cis3
iGMDRD579PF7502
iGMDRD772BRD47702
iGMDRD82Quiflapon2
iGMDRD322FK 8664
iGMDRD414MST-3122
iGMDRD77Itraconazole1
iGMDRD213SMR0000686502
iGMDRD267Oligomycin A2
iGMDRD221Tamoxifen3
iGMDRD137Indisulam7
iGMDRD202Curcumin3
iGMDRD158NSC1415402
iGMDRD57Chloropentafluorobenzene3
iGMDRD560MK-22063

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHB6

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