HSPB1


Summary: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heat shock protein family B (small) member 1MIM:602195Ensembl:ENSG00000106211HGNC:HGNC:5246PA295117q11.23

GO terms in HSPB1


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFISSGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFISSGO:0008426protein kinase C inhibitor activity
MFIPIGO:0019901protein kinase binding
MFIMPGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFISSGO:0043130ubiquitin binding
MFIMPGO:0044183protein binding involved in protein folding
CCISSGO:0000502proteasome complex
CCHDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIEAGO:0005819spindle
CCTASGO:0005829cytosol
CCTASGO:0005856cytoskeleton
CCIEAGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIEAGO:0030018Z disc
CCHDAGO:0070062extracellular exosome
CCIEAGO:1904115axon cytoplasm
BPHEPGO:0001895retina homeostasis
BPIMPGO:0001932regulation of protein phosphorylation
BPTASGO:0006446regulation of translational initiation
BPISSGO:0006469negative regulation of protein kinase activity
BPNASGO:0006986response to unfolded protein
BPIEPGO:0009615response to virus
BPNASGO:0010506regulation of autophagy
BPISSGO:0032731positive regulation of interleukin-1 beta production
BPIMPGO:0035556intracellular signal transduction
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIMPGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
BPISSGO:0042535positive regulation of tumor necrosis factor biosynthetic process
BPTASGO:0043066negative regulation of apoptotic process
BPISSGO:0043122regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0043488regulation of mRNA stability
BPIMPGO:0043536positive regulation of blood vessel endothelial cell migration
BPIMPGO:0045766positive regulation of angiogenesis
BPIMPGO:0061077chaperone-mediated protein folding
BPHMPGO:0070527platelet aggregation
BPIEAGO:0071901negative regulation of protein serine/threonine kinase activity
BPIMPGO:0099641anterograde axonal protein transport
BPISSGO:1902176negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
BPIMPGO:2001028positive regulation of endothelial cell chemotaxis

Gene expression in normal tissue: HSPB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSPB1


DatabasePathway IDPathway Des.
biocartahsp27pathwaystress induction of hsp regulation
biocartamta3pathwaydownregulated of mta-3 in er-negative breast tumors
biocartap38mapkpathwayp38 mapk signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3395Cellular response to heat stress
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3878ATM Signaling Network in Development and Disease
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_IL6IL6
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD82Quiflapon1
iGMDRD300Tozasertib3
iGMDRD505Pevonedistat1
iGMDRD366PI-1033
iGMDRD77Itraconazole3
iGMDRD267Oligomycin A1
iGMDRD481Dactolisib3
iGMDRD6AM-5803
iGMDRD105Triptolide5
iGMDRD227Fatostatin A2
iGMDRD137Indisulam3
iGMDRD202Curcumin6
iGMDRD103SN-386
iGMDRD123Isoevodiamine1
iGMDRD351GW843682X3
iGMDRD698Neratinib3
iGMDRD79Gemcitabine1
iGMDRD405PIK-753
iGMDRD701NVP-AUY9223
iGMDRD486Tosedostat3
iGMDRD640CAY106183
iGMDRD64Parbendazole3
iGMDRD188Piperlongumine3
iGMDRD30917AAG1
iGMDRD513BML-2593
iGMDRD61Kinetin riboside3
iGMDRD193Fqi11
iGMDRD639YK 4-2793
iGMDRD446LY 21832401
iGMDRD546BMS-7548072
iGMDRD144NSC953973
iGMDRD1008SR-II-138A3
iGMDRD151CHM-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPB1

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