ABL1


Summary: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ABL proto-oncogene 1, non-receptor tyrosine kinaseMIM:189980Ensembl:ENSG00000097007HGNC:HGNC:76PA244139q34.12

GO terms in ABL1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000278mitotic cell cycle
BPIEAGO:0001843neural tube closure
BPIEAGO:0001922B-1 B cell homeostasis
BPIMPGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0002322B cell proliferation involved in immune response
BPIEAGO:0002333transitional one stage B cell differentiation
BPTASGO:0006298mismatch repair
BPTASGO:0006355regulation of transcription, DNA-templated
BPNASGO:0006464cellular protein modification process
BPIMPGO:0006468protein phosphorylation
BPIEAGO:0006914autophagy
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006975DNA damage induced protein phosphorylation
BPIGIGO:0006979response to oxidative stress
BPTASGO:0007050cell cycle arrest
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIEAGO:0007173epidermal growth factor receptor signaling pathway
BPIMPGO:0007204positive regulation of cytosolic calcium ion concentration
BPIMPGO:0007229integrin-mediated signaling pathway
BPTASGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0009791post-embryonic development
BPTASGO:0010506regulation of autophagy
BPIMPGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIMPGO:0018108peptidyl-tyrosine phosphorylation
BPTASGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021587cerebellum morphogenesis
BPIEAGO:0022408negative regulation of cell-cell adhesion
BPIEAGO:0030035microspike assembly
BPISSGO:0030036actin cytoskeleton organization
BPTASGO:0030100regulation of endocytosis
BPIBAGO:0030154cell differentiation
BPTASGO:0030155regulation of cell adhesion
BPIEAGO:0030514negative regulation of BMP signaling pathway
BPIMPGO:0030516regulation of axon extension
BPIMPGO:0031113regulation of microtubule polymerization
BPIMPGO:0032489regulation of Cdc42 protein signal transduction
BPIMPGO:0032956regulation of actin cytoskeleton organization
BPIEAGO:0033690positive regulation of osteoblast proliferation
BPIEAGO:0034446substrate adhesion-dependent cell spreading
BPTASGO:0034599cellular response to oxidative stress
BPIMPGO:0035791platelet-derived growth factor receptor-beta signaling pathway
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIDAGO:0038083peptidyl-tyrosine autophosphorylation
BPIMPGO:0038083peptidyl-tyrosine autophosphorylation
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPIMPGO:0038189neuropilin signaling pathway
BPIBAGO:0042127regulation of cell proliferation
BPIDAGO:0042770signal transduction in response to DNA damage
BPIBAGO:0042981regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0043542endothelial cell migration
BPIBAGO:0045087innate immune response
BPIMPGO:0045184establishment of protein localization
BPISSGO:0045580regulation of T cell differentiation
BPIEAGO:0045930negative regulation of mitotic cell cycle
BPIEAGO:0045931positive regulation of mitotic cell cycle
BPIEAGO:0046632alpha-beta T cell differentiation
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0048536spleen development
BPIEAGO:0048538thymus development
BPIEAGO:0048668collateral sprouting
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050798activated T cell proliferation
BPIEAGO:0050853B cell receptor signaling pathway
BPIEAGO:0050885neuromuscular process controlling balance
BPTASGO:0051149positive regulation of muscle cell differentiation
BPIEAGO:0051281positive regulation of release of sequestered calcium ion into cytosol
BPIDAGO:0051353positive regulation of oxidoreductase activity
BPIDAGO:0051444negative regulation of ubiquitin-protein transferase activity
BPTASGO:0051444negative regulation of ubiquitin-protein transferase activity
BPIMPGO:0051496positive regulation of stress fiber assembly
BPTASGO:0051882mitochondrial depolarization
BPIMPGO:0051894positive regulation of focal adhesion assembly
BPIEAGO:0060020Bergmann glial cell differentiation
BPIEAGO:0060563neuroepithelial cell differentiation
BPIDAGO:0070301cellular response to hydrogen peroxide
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIEAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIDAGO:0071901negative regulation of protein serine/threonine kinase activity
BPIEAGO:0072358cardiovascular system development
BPIEAGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIEAGO:0090135actin filament branching
BPIMPGO:1900026positive regulation of substrate adhesion-dependent cell spreading
BPIEAGO:1900042positive regulation of interleukin-2 secretion
BPISSGO:1900272negative regulation of long-term synaptic potentiation
BPIMPGO:1900275negative regulation of phospholipase C activity
BPIEAGO:1901216positive regulation of neuron death
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
BPIEAGO:1902715positive regulation of interferon-gamma secretion
BPIEAGO:1903053regulation of extracellular matrix organization
BPTASGO:1903351cellular response to dopamine
BPIMPGO:1904528positive regulation of microtubule binding
BPIMPGO:1904531positive regulation of actin filament binding
BPISSGO:1905244regulation of modification of synaptic structure
BPIEAGO:1905555positive regulation blood vessel branching
BPIDAGO:1990051activation of protein kinase C activity
BPIEAGO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway
BPTASGO:2000145regulation of cell motility
BPTASGO:2000249regulation of actin cytoskeleton reorganization
BPIMPGO:2000251positive regulation of actin cytoskeleton reorganization
BPIEAGO:2000352negative regulation of endothelial cell apoptotic process
BPIEAGO:2000773negative regulation of cellular senescence
BPIDAGO:2001020regulation of response to DNA damage stimulus
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCNASGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCNASGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0015629actin cytoskeleton
CCIDAGO:0016604nuclear body
CCISSGO:0030425dendrite
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIEAGO:0031252cell leading edge
CCIEAGO:0031965nuclear membrane
CCIPIGO:0032991protein-containing complex
CCISSGO:0043025neuronal cell body
CCIDAGO:0048471perinuclear region of cytoplasm
CCTASGO:0098794postsynapse
MFIDAGO:0000287magnesium ion binding
MFIPIGO:0001784phosphotyrosine residue binding
MFNASGO:0003677DNA binding
MFTASGO:0003785actin monomer binding
MFTASGO:0004515nicotinate-nucleotide adenylyltransferase activity
MFIDAGO:0004672protein kinase activity
MFIMPGO:0004672protein kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIMPGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIDAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIMPGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005080protein kinase C binding
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIPIGO:0008022protein C-terminus binding
MFIMPGO:0016301kinase activity
MFIPIGO:0017124SH3 domain binding
MFIPIGO:0019905syntaxin binding
MFIDAGO:0030145manganese ion binding
MFIPIGO:0038191neuropilin binding
MFIPIGO:0042169SH2 domain binding
MFISSGO:0046875ephrin receptor binding
MFIEAGO:0051015actin filament binding
MFIPIGO:0051019mitogen-activated protein kinase binding
MFIDAGO:0070064proline-rich region binding
MFIPIGO:0070064proline-rich region binding

Gene expression in normal tissue: ABL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABL1


DatabasePathway IDPathway Des.
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartaatmpathwayatm signaling pathway
biocartag1pathwaycell cycle: g1/s check point
biocartalis1pathwaylissencephaly gene (lis1) in neuronal migration and development
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-428890Role of ABL in ROBO-SLIT signaling
reactomeR-HSA-428890Role of ABL in ROBO-SLIT signaling
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1545miRNAs involved in DNA damage response
wikipathwaysWP1742TP53 Network
wikipathwaysWP179Cell Cycle
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP2272Pathogenic Escherichia coli infection
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP4223Ras Signaling
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pharmgkbPA164713427Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidatm_pathwayATM pathway
pidlis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
pidp53regulationpathwayp53 pathway
pidp73pathwayp73 transcription factor network
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrb_1pathwayRegulation of retinoblastoma protein
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
pidtelomerasepathwayRegulation of Telomerase
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_EGFR1EGFR1
netpathPathway_KitReceptorKitReceptor
netpathPathway_TCRTCR

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD887Compound 23 citrate2
iGMDRD577BIX012942
iGMDRD562Navitoclax4
iGMDRD190Nilotinib29
iGMDRD41Imatinib462
iGMDRD23Gossypol3
iGMDRD602Foretinib1
iGMDRD834BCR-ABL1 inhibitors1
iGMDRD885Compound 1102
iGMDRD152179324-69-72
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B3
iGMDRD828AURK inhibitor1
iGMDRD126Tipifarnib3
iGMDRD571Cabozantinib1
iGMDRD313Axitinib2
iGMDRD427ABT7372
iGMDRD239Dasatinib41
iGMDRD283Bosutinib17
iGMDRD67PENFLURIDOL4
iGMDRD414MST-3123
iGMDRD882CIL412
iGMDRD872BRD71373
iGMDRD1030Tyrosine kinase inhibitor105
iGMDRD505Pevonedistat3
iGMDRD271Brefeldin A2
iGMDRD221Tamoxifen2
iGMDRD6AM-5803
iGMDRD289Parthenolide1
iGMDRD434BMS-5369243
iGMDRD551Ponatinib31
iGMDRD240Vandetanib1
iGMDRD945ML2146
iGMDRD456Crizotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABL1

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