AREG
Summary: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| amphiregulin | MIM:104640 | Ensembl:ENSG00000109321 | HGNC:HGNC:651 | PA24933 | 4q13.3 |
GO terms in AREG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IBA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0014009 | glial cell proliferation |
| BP | IEA | GO:0031175 | neuron projection development |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IEA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IEA | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis |
| BP | IEA | GO:0060744 | mammary gland branching involved in thelarche |
| BP | IEA | GO:0060749 | mammary gland alveolus development |
| BP | IEA | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
Gene expression in normal tissue: AREG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AREG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP288 | NLR Proteins |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| wikipathways | WP673 | ErbB Signaling Pathway |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5694530 | Cargo concentration in the ER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD792 | Cetuximab | 2 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD898 | EGFR mAb inhibitor | 2 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD858 | BRD-K71935468 | 1 |
| iGMDRD34 | Nilutamide | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD456 | Crizotinib | 2 |
| iGMDRD342 | Orteronel | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD69 | Dirigestran | 1 |
| iGMDRD823 | AR inhibitor next gen | 2 |
| iGMDRD511 | CHEMBL399379 | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD58 | Cyproterone Acetate | 1 |
| iGMDRD953 | next-generation AR antagonists | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD114 | Abiraterone | 10 |
| iGMDRD967 | Panitumumab | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD412 | VX-702 | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD179 | Shikonin | 1 |
| iGMDRD128 | 4-Hydroxytestosterone | 1 |
| iGMDRD12 | Bicalutamide | 4 |
| iGMDRD555 | ARN-509 | 7 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD301 | Ketoconazole | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD487 | Enzalutamide | 16 |
| iGMDRD385 | CD1530 | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD22 | Flutamide | 8 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD816 | anti-EGFR mAbs | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD306 | Androgen | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD431 | NU-7441 | 1 |
| iGMDRD64 | Parbendazole | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AREG
CLASSFICATION
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