CD79B


Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CD79b moleculeMIM:147245Ensembl:ENSG00000007312HGNC:HGNC:1699PA2623817q23.3

GO terms in CD79B


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIMPGO:0042803protein homodimerization activity
BPIEAGO:0002250adaptive immune response
BPTASGO:0006955immune response
BPTASGO:0007165signal transduction
BPIBAGO:0030183B cell differentiation
BPIBAGO:0050853B cell receptor signaling pathway
BPIMPGO:0051260protein homooligomerization
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIBAGO:0019815B cell receptor complex
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: CD79B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD79B


DatabasePathway IDPathway Des.
pidbcr_5pathwayBCR signaling pathway
netpathPathway_BCRBCR
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
wikipathwaysWP23B Cell Receptor Signaling Pathway
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-5690714CD22 mediated BCR regulation
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartabcrpathwaybcr signaling pathway
biocartactcfpathwayctcf: first multivalent nuclear factor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib3
iGMDRD889Compound 7d-cis3
iGMDRD1008SR-II-138A3
iGMDRD546BMS-7548073
iGMDRD781Sirolimus3
iGMDRD280CYTOCHALASIN B3
iGMDRD679Bistramide A5
iGMDRD359OSW-13
iGMDRD474Avrainvillamide2
iGMDRD885Compound 1106
iGMDRD318PAC-17
iGMDRD226ML0063
iGMDRD399Selumetinib3
iGMDRD506Fedratinib3
iGMDRD577BIX012943
iGMDRD780PP-303
iGMDRD562Navitoclax3
iGMDRD60Quinoclamine3
iGMDRD524ISX-96
iGMDRD523Cyanoquinoline, 113
iGMDRD219Bax channel blocker3
iGMDRD945ML2143
iGMDRD289Parthenolide1
iGMDRD481Dactolisib3
iGMDRD267Oligomycin A6
iGMDRD871BRD63683
iGMDRD872BRD71376
iGMDRD329Merck603
iGMDRD366PI-1033
iGMDRD886Compound 1541A6
iGMDRD300Tozasertib3
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD79B

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