CD79B
Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
CD79b molecule | MIM:147245 | Ensembl:ENSG00000007312 | HGNC:HGNC:1699 | PA26238 | 17q23.3 |
GO terms in CD79B
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IMP | GO:0042803 | protein homodimerization activity |
BP | IEA | GO:0002250 | adaptive immune response |
BP | TAS | GO:0006955 | immune response |
BP | TAS | GO:0007165 | signal transduction |
BP | IBA | GO:0030183 | B cell differentiation |
BP | IBA | GO:0050853 | B cell receptor signaling pathway |
BP | IMP | GO:0051260 | protein homooligomerization |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | IDA | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | IBA | GO:0009897 | external side of plasma membrane |
CC | IBA | GO:0019815 | B cell receptor complex |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CD79B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD79B
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | bcr_5pathway | BCR signaling pathway |
netpath | Pathway_BCR | BCR |
kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
wikipathways | WP23 | B Cell Receptor Signaling Pathway |
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-5690714 | CD22 mediated BCR regulation |
reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
biocarta | bcrpathway | bcr signaling pathway |
biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD126 | Tipifarnib | 3 |
iGMDRD889 | Compound 7d-cis | 3 |
iGMDRD1008 | SR-II-138A | 3 |
iGMDRD546 | BMS-754807 | 3 |
iGMDRD781 | Sirolimus | 3 |
iGMDRD280 | CYTOCHALASIN B | 3 |
iGMDRD679 | Bistramide A | 5 |
iGMDRD359 | OSW-1 | 3 |
iGMDRD474 | Avrainvillamide | 2 |
iGMDRD885 | Compound 110 | 6 |
iGMDRD318 | PAC-1 | 7 |
iGMDRD226 | ML006 | 3 |
iGMDRD399 | Selumetinib | 3 |
iGMDRD506 | Fedratinib | 3 |
iGMDRD577 | BIX01294 | 3 |
iGMDRD780 | PP-30 | 3 |
iGMDRD562 | Navitoclax | 3 |
iGMDRD60 | Quinoclamine | 3 |
iGMDRD524 | ISX-9 | 6 |
iGMDRD523 | Cyanoquinoline, 11 | 3 |
iGMDRD219 | Bax channel blocker | 3 |
iGMDRD945 | ML214 | 3 |
iGMDRD289 | Parthenolide | 1 |
iGMDRD481 | Dactolisib | 3 |
iGMDRD267 | Oligomycin A | 6 |
iGMDRD871 | BRD6368 | 3 |
iGMDRD872 | BRD7137 | 6 |
iGMDRD329 | Merck60 | 3 |
iGMDRD366 | PI-103 | 3 |
iGMDRD886 | Compound 1541A | 6 |
iGMDRD300 | Tozasertib | 3 |
iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD79B