CSK


Summary: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
C-terminal Src kinaseMIM:124095Ensembl:ENSG00000103653HGNC:HGNC:2444PA2694615q24.1

GO terms in CSK


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0001817regulation of cytokine production
BPIEAGO:0002250adaptive immune response
BPTASGO:0006468protein phosphorylation
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIEAGO:0007420brain development
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0010989negative regulation of low-density lipoprotein particle clearance
BPIBAGO:0030154cell differentiation
BPTASGO:0031295T cell costimulation
BPIEAGO:0032715negative regulation of interleukin-6 production
BPIEAGO:0033673negative regulation of kinase activity
BPIBAGO:0034332adherens junction organization
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042127regulation of cell proliferation
BPIDAGO:0042997negative regulation of Golgi to plasma membrane protein transport
BPIEAGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0045087innate immune response
BPIEAGO:0045779negative regulation of bone resorption
BPIEAGO:0048709oligodendrocyte differentiation
BPIEAGO:0050765negative regulation of phagocytosis
BPTASGO:0050852T cell receptor signaling pathway
BPIBAGO:0060368regulation of Fc receptor mediated stimulatory signaling pathway
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIEAGO:0071375cellular response to peptide hormone stimulus
CCISSGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIPIGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005911cell-cell junction
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIEAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0008022protein C-terminus binding
MFTASGO:0016301kinase activity
MFIEAGO:0019903protein phosphatase binding
MFIPIGO:0034236protein kinase A catalytic subunit binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0070064proline-rich region binding

Gene expression in normal tissue: CSK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSK


DatabasePathway IDPathway Des.
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidcxcr4_pathwayCXCR4-mediated signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pharmgkbPA2032VEGF Signaling Pathway
netpathPathway_EGFR1EGFR1
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
biocartacell2cellpathwaycell to cell adhesion signaling
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaintegrinpathwayintegrin signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-180292GAB1 signalosome
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202427Phosphorylation of CD3 and TCR zeta chains
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389948PD-1 signaling
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-9006921Integrin signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD562Navitoclax2
iGMDRD888Compound 443
iGMDRD577BIX012943
iGMDRD872BRD71374
iGMDRD399Selumetinib6
iGMDRD414MST-3123
iGMDRD286Nsc 6328393
iGMDRD524ISX-96
iGMDRD82Quiflapon3
iGMDRD356PNU-746543
iGMDRD300Tozasertib5
iGMDRD137Indisulam3
iGMDRD267Oligomycin A2
iGMDRD318PAC-14
iGMDRD226ML0063
iGMDRD885Compound 1106
iGMDRD481Dactolisib4
iGMDRD289Parthenolide1
iGMDRD219Bax channel blocker2
iGMDRD945ML2143
iGMDRD634SCHEMBL26080413
iGMDRD148Pifithrin-mu2
iGMDRD1008SR-II-138A3
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib7
iGMDRD781Sirolimus8
iGMDRD523Cyanoquinoline, 113
iGMDRD427ABT7372
iGMDRD546BMS-7548073

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSK

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