EIF2AK4


Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
eukaryotic translation initiation factor 2 alpha kinase 4MIM:609280Ensembl:ENSG00000128829HGNC:HGNC:19687PA13494761615q15.1

GO terms in EIF2AK4


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000049tRNA binding
MFIBAGO:0004672protein kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIMPGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFISSGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIEAGO:0005524ATP binding
BPIEAGO:0000077DNA damage checkpoint
BPISSGO:0002230positive regulation of defense response to virus by host
BPIEAGO:0002250adaptive immune response
BPISSGO:0002286T cell activation involved in immune response
BPISSGO:0002821positive regulation of adaptive immune response
BPISSGO:0006446regulation of translational initiation
BPISSGO:0006468protein phosphorylation
BPIEAGO:0007050cell cycle arrest
BPISSGO:0007612learning
BPISSGO:0007616long-term memory
BPIMPGO:0010998regulation of translational initiation by eIF2 alpha phosphorylation
BPISSGO:0010998regulation of translational initiation by eIF2 alpha phosphorylation
BPISSGO:0019081viral translation
BPISSGO:0032057negative regulation of translational initiation in response to stress
BPISSGO:0032792negative regulation of CREB transcription factor activity
BPIMPGO:0034198cellular response to amino acid starvation
BPISSGO:0034198cellular response to amino acid starvation
BPISSGO:0034644cellular response to UV
BPIMPGO:0036492eiF2alpha phosphorylation in response to endoplasmic reticulum stress
BPISSGO:0039520induction by virus of host autophagy
BPISSGO:0044828negative regulation by host of viral genome replication
BPISSGO:0045665negative regulation of neuron differentiation
BPISSGO:0045947negative regulation of translational initiation
BPISSGO:0046777protein autophosphorylation
BPIEAGO:0051607defense response to virus
BPISSGO:0060259regulation of feeding behavior
BPIMPGO:0060733regulation of eIF2 alpha phosphorylation by amino acid starvation
BPISSGO:0060733regulation of eIF2 alpha phosphorylation by amino acid starvation
BPIMPGO:0070417cellular response to cold
BPISSGO:0071264positive regulation of translational initiation in response to starvation
BPISSGO:1900273positive regulation of long-term synaptic potentiation
BPISSGO:1990138neuron projection extension
BPISSGO:1990253cellular response to leucine starvation
CCISSGO:0005844polysome
CCIBAGO:0022626cytosolic ribosome
CCISSGO:0022626cytosolic ribosome

Gene expression in normal tissue: EIF2AK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF2AK4


DatabasePathway IDPathway Des.
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
biocartaeif2pathwayregulation of eif2

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD177Teniposide6
iGMDRD154NSC237663
iGMDRD314Tanespimycin2
iGMDRD351GW843682X2
iGMDRD512nutlin 33
iGMDRD148Pifithrin-mu3
iGMDRD505Pevonedistat4
iGMDRD147Prima-11
iGMDRD42Vorinostat3
iGMDRD872BRD71373
iGMDRD705Nakiterpiosin1
iGMDRD103SN-385
iGMDRD158NSC1415402
iGMDRD137Indisulam3
iGMDRD297Austocystin D3
iGMDRD280CYTOCHALASIN B2
iGMDRD359OSW-13
iGMDRD427ABT7373
iGMDRD144NSC953972
iGMDRD779PRL-3 Inhibitor I6
iGMDRD494Neopeltolide3
iGMDRD483SCH-5290746
iGMDRD781Sirolimus3
iGMDRD151CHM-13
iGMDRD420Leucascandrolide A5
iGMDRD772BRD47702
iGMDRD60Quinoclamine5
iGMDRD399Selumetinib2
iGMDRD562Navitoclax3
iGMDRD398Sepantronium2
iGMDRD171Pemetrexed2
iGMDRD318PAC-12
iGMDRD870BRD636101
iGMDRD260FQI-23

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF2AK4

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