WRN


Summary: This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Werner syndrome RecQ like helicaseMIM:604611Ensembl:ENSG00000165392HGNC:HGNC:12791PA3678p12

Gene Categories:

DNA REPAIR

GO terms in WRN


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000287magnesium ion binding
MFIDAGO:0000287magnesium ion binding
MFIBAGO:0000400four-way junction DNA binding
MFIDAGO:0000400four-way junction DNA binding
MFIBAGO:0000403Y-form DNA binding
MFIDAGO:0000403Y-form DNA binding
MFIBAGO:0000405bubble DNA binding
MFIDAGO:0000405bubble DNA binding
MFIBAGO:0003677DNA binding
MFIDAGO:0003677DNA binding
MFIDAGO:0003678DNA helicase activity
MFIMPGO:0003678DNA helicase activity
MFIBAGO:0003682chromatin binding
MFIEAGO:0003682chromatin binding
MFIDAGO:0004003ATP-dependent DNA helicase activity
MFIDAGO:0004386helicase activity
MFIDAGO:0004527exonuclease activity
MFIMPGO:0004527exonuclease activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:00084083'-5' exonuclease activity
MFIDAGO:00084083'-5' exonuclease activity
MFIBAGO:0009378four-way junction helicase activity
MFIDAGO:0009378four-way junction helicase activity
MFIDAGO:0016887ATPase activity
MFIBAGO:0030145manganese ion binding
MFIDAGO:0030145manganese ion binding
MFIBAGO:0042803protein homodimerization activity
MFIDAGO:0042803protein homodimerization activity
MFIDAGO:00431383'-5' DNA helicase activity
MFIBAGO:0043140ATP-dependent 3'-5' DNA helicase activity
MFIDAGO:0044877protein-containing complex binding
MFIDAGO:0051880G-quadruplex DNA binding
MFIBAGO:0061749forked DNA-dependent helicase activity
MFIDAGO:0061749forked DNA-dependent helicase activity
MFIBAGO:0061821telomeric D-loop binding
MFIDAGO:0061821telomeric D-loop binding
MFICGO:0061849telomeric G-quadruplex DNA binding
MFIBAGO:00703373'-flap-structured DNA binding
MFIDAGO:00703373'-flap-structured DNA binding
MFIBAGO:19057738-hydroxy-2'-deoxyguanosine DNA binding
MFIDAGO:19057738-hydroxy-2'-deoxyguanosine DNA binding
CCIBAGO:0000781chromosome, telomeric region
CCIDAGO:0000781chromosome, telomeric region
CCIBAGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005657replication fork
CCISSGO:0005657replication fork
CCIBAGO:0005662DNA replication factor A complex
CCIBAGO:0005694chromosome
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCIBAGO:0005813centrosome
CCIDAGO:0005813centrosome
CCIDAGO:0016607nuclear speck
CCIBAGO:0032389MutLalpha complex
CCIDAGO:0032389MutLalpha complex
CCIBAGO:0035861site of double-strand break
CCIEAGO:0043005neuron projection
BPIMPGO:0000723telomere maintenance
BPTASGO:0000723telomere maintenance
BPIBAGO:0000724double-strand break repair via homologous recombination
BPIBAGO:0000731DNA synthesis involved in DNA repair
BPIDAGO:0000731DNA synthesis involved in DNA repair
BPIBAGO:0001302replicative cell aging
BPIEAGO:0001302replicative cell aging
BPIDAGO:0006259DNA metabolic process
BPIMPGO:0006260DNA replication
BPISSGO:0006260DNA replication
BPTASGO:0006260DNA replication
BPIBAGO:0006281DNA repair
BPIBAGO:0006284base-excision repair
BPIDAGO:0006284base-excision repair
BPIMPGO:0006302double-strand break repair
BPIBAGO:0006310DNA recombination
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIBAGO:0006979response to oxidative stress
BPIDAGO:0006979response to oxidative stress
BPIEAGO:0007420brain development
BPNASGO:0007568aging
BPIBAGO:0007569cell aging
BPIMPGO:0007569cell aging
BPIBAGO:0008340determination of adult lifespan
BPIBAGO:0009267cellular response to starvation
BPIDAGO:0009267cellular response to starvation
BPIBAGO:0010225response to UV-C
BPIDAGO:0010225response to UV-C
BPIBAGO:0010259multicellular organism aging
BPIMPGO:0010259multicellular organism aging
BPIBAGO:0031297replication fork processing
BPIDAGO:0031297replication fork processing
BPIMPGO:0031297replication fork processing
BPIBAGO:0032508DNA duplex unwinding
BPIDAGO:0032508DNA duplex unwinding
BPIEAGO:0040009regulation of growth rate
BPIBAGO:0042981regulation of apoptotic process
BPIGIGO:0042981regulation of apoptotic process
BPIBAGO:0044806G-quadruplex DNA unwinding
BPIDAGO:0044806G-quadruplex DNA unwinding
BPISSGO:0044806G-quadruplex DNA unwinding
BPIBAGO:0051345positive regulation of hydrolase activity
BPIDAGO:0051345positive regulation of hydrolase activity
BPIBAGO:0061820telomeric D-loop disassembly
BPIDAGO:0061820telomeric D-loop disassembly
BPIGIGO:0061820telomeric D-loop disassembly
BPTASGO:0061820telomeric D-loop disassembly
BPIBAGO:0071480cellular response to gamma radiation
BPIDAGO:0071480cellular response to gamma radiation
BPIEAGO:0090305nucleic acid phosphodiester bond hydrolysis
BPTASGO:0090656t-circle formation
BPIBAGO:0098530positive regulation of strand invasion
BPIDAGO:0098530positive regulation of strand invasion
BPIDAGO:1902570protein localization to nucleolus

Gene expression in normal tissue: WRN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WRN


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693537Resolution of D-Loop Structures
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
pidtelomerasepathwayRegulation of Telomerase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1593-Chloro-L-alanine3
iGMDRD634SCHEMBL26080415
iGMDRD446LY 21832404
iGMDRD781Sirolimus2
iGMDRD484Pluripotin2
iGMDRD1008SR-II-138A2
iGMDRD889Compound 7d-cis2
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine3
iGMDRD399Selumetinib2
iGMDRD100Zebularine2
iGMDRD188Piperlongumine5
iGMDRD562Navitoclax1
iGMDRD888Compound 442
iGMDRD782DC-45-A22
iGMDRD207Capsaicin2
iGMDRD870BRD636101
iGMDRD187BRD98763
iGMDRD513BML-2592
iGMDRD8024-methylfasudil1
iGMDRD123Isoevodiamine2
iGMDRD85Ursolic acid2
iGMDRD237ABT-7511
iGMDRD57Chloropentafluorobenzene2
iGMDRD698Neratinib3
iGMDRD351GW843682X3
iGMDRD299ICL 6701
iGMDRD246NPC262
iGMDRD322FK 8666
iGMDRD286Nsc 6328393
iGMDRD366PI-1031
iGMDRD329Merck601
iGMDRD434BMS-5369247
iGMDRD289Parthenolide2
iGMDRD705Nakiterpiosin2
iGMDRD213SMR0000686502
iGMDRD77Itraconazole5
iGMDRD121GMX17783
iGMDRD202Curcumin2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WRN

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