CARD11


Summary: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
caspase recruitment domain family member 11MIM:607210Ensembl:ENSG00000198286HGNC:HGNC:16393PA260737p22.2

GO terms in CARD11


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0001819positive regulation of cytokine production
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIEAGO:0002377immunoglobulin production
BPIMPGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0030183B cell differentiation
BPIEAGO:0030890positive regulation of B cell proliferation
BPIDAGO:0031295T cell costimulation
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIMPGO:0038202TORC1 signaling
BPIEAGO:0042100B cell proliferation
BPIEAGO:0042102positive regulation of T cell proliferation
BPIEAGO:0042981regulation of apoptotic process
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0045061thymic T cell selection
BPIEAGO:0045086positive regulation of interleukin-2 biosynthetic process
BPIEAGO:0045577regulation of B cell differentiation
BPIEAGO:0045580regulation of T cell differentiation
BPIEAGO:0046037GMP metabolic process
BPIEAGO:0046710GDP metabolic process
BPIEAGO:0048872homeostasis of number of cells
BPTASGO:0050852T cell receptor signaling pathway
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0070970interleukin-2 secretion
CCIEAGO:0001772immunological synapse
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0032449CBM complex
CCIDAGO:0042101T cell receptor complex
CCIDAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
MFNASGO:0004385guanylate kinase activity
MFIPIGO:0005515protein binding
MFIPIGO:0050700CARD domain binding

Gene expression in normal tissue: CARD11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CARD11


DatabasePathway IDPathway Des.
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
netpathPathway_BCRBCR
netpathPathway_TCRTCR
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD52Rotenone1
iGMDRD289Parthenolide3
iGMDRD434BMS-5369246
iGMDRD5Tyrphostin AG 14783
iGMDRD255SB2250023
iGMDRD886Compound 1541A3
iGMDRD300Tozasertib3
iGMDRD60Quinoclamine3
iGMDRD329Merck606
iGMDRD562Navitoclax3
iGMDRD188Piperlongumine4
iGMDRD414MST-3123
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate5
iGMDRD150RITA3
iGMDRD424Tamatinib2
iGMDRD546BMS-7548072
iGMDRD670ML 2103
iGMDRD144NSC953975
iGMDRD772BRD47702
iGMDRD248BRD43541
iGMDRD48Dexamethasone3
iGMDRD126Tipifarnib4
iGMDRD634SCHEMBL26080415
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD945ML2143
iGMDRD211(1S,3R)-RSL33
iGMDRD901ELCPK1
iGMDRD394BX-7953
iGMDRD351GW843682X6
iGMDRD201SKI II1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARD11

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