CHEK1
Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| checkpoint kinase 1 | MIM:603078 | Ensembl:ENSG00000149554 | HGNC:HGNC:1925 | PA110 | 11q24.2 |
GO terms in CHEK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IDA | GO:0035402 | histone kinase activity (H3-T11 specific) |
| BP | IDA | GO:0000077 | DNA damage checkpoint |
| BP | IMP | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IMP | GO:0006281 | DNA repair |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0006975 | DNA damage induced protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0010569 | regulation of double-strand break repair via homologous recombination |
| BP | ISS | GO:0010767 | regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IEA | GO:0035407 | histone H3-T11 phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0045787 | positive regulation of cell cycle |
| BP | IDA | GO:0045839 | negative regulation of mitotic nuclear division |
| BP | IDA | GO:0046602 | regulation of mitotic centrosome separation |
| BP | ISS | GO:0048096 | chromatin-mediated maintenance of transcription |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IMP | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint |
| BP | NAS | GO:0090399 | replicative senescence |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | ISS | GO:2000615 | regulation of histone H3-K9 acetylation |
| CC | IDA | GO:0000781 | chromosome, telomeric region |
| CC | ISS | GO:0000785 | chromatin |
| CC | IDA | GO:0000794 | condensed nuclear chromosome |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: CHEK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHEK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP3808 | TP53 Regulates Transcription of DNA Repair Genes |
| wikipathways | WP3875 | ATR Signaling |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP707 | DNA Damage Response |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | atr_pathway | ATR signaling pathway |
| pid | circadianpathway | Circadian rhythm pathway |
| pid | fanconi_pathway | Fanconi anemia pathway |
| pid | p53regulationpathway | p53 pathway |
| pid | p73pathway | p73 transcription factor network |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | atrbrcapathway | role of brca1 brca2 and atr in cancer susceptibility |
| biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| reactome | R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| reactome | R-HSA-69610 | p53-Independent DNA Damage Response |
| reactome | R-HSA-69610 | p53-Independent DNA Damage Response |
| reactome | R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint |
| reactome | R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD206 | SJ-172550 | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD95 | Isonicotinohydroxamic acid | 1 |
| iGMDRD154 | NSC23766 | 7 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD1036 | X17AAG | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD947 | ML334 diastereomer | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD391 | OSU-03012 | 1 |
| iGMDRD140 | NSC19630 | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD598 | QS-11 | 1 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD802 | 4-methylfasudil | 5 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD112 | Methotrexate | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHEK1
CLASSFICATION
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