CPAMD8
Summary: This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C3 and PZP like, alpha-2-macroglobulin domain containing 8 | MIM:608841 | Ensembl:ENSG00000160111 | HGNC:HGNC:23228 | PA134915057 | 19p13.11 |
GO terms in CPAMD8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005886 | plasma membrane |
| BP | IMP | GO:0001654 | eye development |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
Gene expression in normal tissue: CPAMD8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPAMD8
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD780 | PP-30 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD560 | MK-2206 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPAMD8
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.