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GLI1

Summary: This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
GLI family zinc finger 1	MIM:165220	Ensembl:ENSG00000111087	HGNC:HGNC:4317	PA28720	12q13.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in GLI1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0001649	osteoblast differentiation
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IDA	GO:0007224	smoothened signaling pathway
BP	TAS	GO:0007224	smoothened signaling pathway
BP	IEA	GO:0007283	spermatogenesis
BP	IEA	GO:0007418	ventral midline development
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	TAS	GO:0008589	regulation of smoothened signaling pathway
BP	IEA	GO:0009611	response to wounding
BP	IDA	GO:0009913	epidermal cell differentiation
BP	IEA	GO:0009953	dorsal/ventral pattern formation
BP	IEA	GO:0009954	proximal/distal pattern formation
BP	IEA	GO:0021696	cerebellar cortex morphogenesis
BP	IEA	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
BP	IEA	GO:0021983	pituitary gland development
BP	IEA	GO:0030324	lung development
BP	IEA	GO:0030850	prostate gland development
BP	IEA	GO:0045667	regulation of osteoblast differentiation
BP	IDA	GO:0045740	positive regulation of DNA replication
BP	IDA	GO:0045880	positive regulation of smoothened signaling pathway
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	TAS	GO:0048546	digestive tract morphogenesis
BP	IEA	GO:0060032	notochord regression
BP	IDA	GO:0060045	positive regulation of cardiac muscle cell proliferation
BP	IEA	GO:0060070	canonical Wnt signaling pathway
BP	IMP	GO:0090090	negative regulation of canonical Wnt signaling pathway
BP	IEA	GO:0097421	liver regeneration
BP	IDA	GO:1902808	positive regulation of cell cycle G1/S phase transition
BP	IEA	GO:2000345	regulation of hepatocyte proliferation
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005930	axoneme
CC	TAS	GO:0097542	ciliary tip
CC	TAS	GO:0097546	ciliary base
MF	IDA	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding
MF	IEA	GO:0003682	chromatin binding
MF	IEA	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008017	microtubule binding
MF	IDA	GO:0044212	transcription regulatory region DNA binding
MF	IEA	GO:0046872	metal ion binding

Gene expression in normal tissue: GLI1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GLI1

Database	Pathway ID	Pathway Des.
wikipathways	WP2855	Dopaminergic Neurogenesis
wikipathways	WP3313	Hedgehog ,on, state
wikipathways	WP3316	Hedgehog ,off, state
wikipathways	WP3930	EDA Signalling in Hair Follicle Development
wikipathways	WP4204	Tumor suppressor activity of SMARCB1
wikipathways	WP4249	Hedgehog Signaling Pathway
wikipathways	WP47	Hedgehog Signaling Pathway
netpath	Pathway_Hedgehog	Hedgehog
pid	hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins
kegg	hsa04024	cAMP signaling pathway - Homo sapiens (human)
kegg	hsa04340	Hedgehog signaling pathway - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05217	Basal cell carcinoma - Homo sapiens (human)
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-5358351	Signaling by Hedgehog
reactome	R-HSA-5358351	Signaling by Hedgehog
reactome	R-HSA-5610780	Degradation of GLI1 by the proteasome
reactome	R-HSA-5610780	Degradation of GLI1 by the proteasome
reactome	R-HSA-5610787	Hedgehog 'off' state
reactome	R-HSA-5610787	Hedgehog 'off' state
reactome	R-HSA-5632684	Hedgehog 'on' state
reactome	R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD886	Compound 1541A	2
iGMDRD300	Tozasertib	4
iGMDRD67	PENFLURIDOL	4
iGMDRD871	BRD6368	3
iGMDRD286	Nsc 632839	1
iGMDRD434	BMS-536924	5
iGMDRD705	Nakiterpiosin	3
iGMDRD6	AM-580	8
iGMDRD231	Importazole	2
iGMDRD137	Indisulam	2
iGMDRD158	NSC141540	2
iGMDRD123	Isoevodiamine	1
iGMDRD901	ELCPK	1
iGMDRD154	NSC23766	4
iGMDRD237	ABT-751	2
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD351	GW843682X	3
iGMDRD116	CD437	3
iGMDRD64	Parbendazole	2
iGMDRD730	Kahalalide F	2
iGMDRD74	Idarubicin	2
iGMDRD506	Fedratinib	2
iGMDRD577	BIX01294	3
iGMDRD294	Batimastat	4
iGMDRD318	PAC-1	3
iGMDRD474	Avrainvillamide	4
iGMDRD138	PX 12	2
iGMDRD255	SB225002	4
iGMDRD446	LY 2183240	2
iGMDRD639	YK 4-279	2
iGMDRD427	ABT737	1
iGMDRD484	Pluripotin	2
iGMDRD433	Lexibulin	3
iGMDRD420	Leucascandrolide A	2
iGMDRD599	Salermide	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLI1

SITE

DATATYPES

CLASSFICATION

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