PTPRU


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein tyrosine phosphatase, receptor type UMIM:602454Ensembl:ENSG00000060656HGNC:HGNC:9683PA340281p35.3

GO terms in PTPRU


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006470protein dephosphorylation
BPNASGO:0007155cell adhesion
BPNASGO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway
BPIDAGO:0008285negative regulation of cell proliferation
BPIEAGO:0030154cell differentiation
BPIDAGO:0030336negative regulation of cell migration
BPIEAGO:0031100animal organ regeneration
BPIEAGO:0034109homotypic cell-cell adhesion
BPIDAGO:0034394protein localization to cell surface
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
BPIEAGO:0051384response to glucocorticoid
BPIDAGO:0060070canonical Wnt signaling pathway
BPIDAGO:0098609cell-cell adhesion
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIDAGO:0005911cell-cell junction
MFIDAGO:0004725protein tyrosine phosphatase activity
MFIMPGO:0004725protein tyrosine phosphatase activity
MFNASGO:0005001transmembrane receptor protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008013beta-catenin binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: PTPRU

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRU


DatabasePathway IDPathway Des.
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
netpathPathway_KitReceptorKitReceptor
wikipathwaysWP581EPO Receptor Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD782DC-45-A23
iGMDRD870BRD636105
iGMDRD318PAC-13
iGMDRD399Selumetinib2
iGMDRD562Navitoclax2
iGMDRD398Sepantronium2
iGMDRD506Fedratinib8
iGMDRD888Compound 443
iGMDRD23Gossypol2
iGMDRD126Tipifarnib3
iGMDRD670ML 2103
iGMDRD144NSC953973
iGMDRD427ABT7372
iGMDRD280CYTOCHALASIN B2
iGMDRD466Chaetocin2
iGMDRD394BX-7951
iGMDRD121GMX17782
iGMDRD137Indisulam1
iGMDRD103SN-382
iGMDRD705Nakiterpiosin2
iGMDRD289Parthenolide2
iGMDRD213SMR0000686502
iGMDRD481Dactolisib2
iGMDRD329Merck604
iGMDRD147Prima-14
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib6
iGMDRD322FK 8661
iGMDRD353PD03259011
iGMDRD150RITA3
iGMDRD351GW843682X7
iGMDRD123Isoevodiamine2
iGMDRD132(-)-gallocatechin-3-O-gallate6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRU

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