RXRA


Summary: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
retinoid X receptor alphaMIM:180245Ensembl:ENSG00000186350HGNC:HGNC:10477PA348909q34.2

GO terms in RXRA


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0032991protein-containing complex
CCIDAGO:0043235receptor complex
CCIDAGO:0090575RNA polymerase II transcription factor complex
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001893maternal placenta development
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006766vitamin metabolic process
BPIEAGO:0007566embryo implantation
BPTASGO:0008203cholesterol metabolic process
BPTASGO:0015721bile acid and bile salt transport
BPIDAGO:0019048modulation by virus of host morphology or physiology
BPTASGO:0019216regulation of lipid metabolic process
BPIMPGO:0032526response to retinoic acid
BPIDAGO:0035357peroxisome proliferator activated receptor signaling pathway
BPIEAGO:0043010camera-type eye development
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045994positive regulation of translational initiation by iron
BPIMPGO:0048384retinoic acid receptor signaling pathway
BPIDAGO:0051289protein homotetramerization
BPIEAGO:0055010ventricular cardiac muscle tissue morphogenesis
BPIEAGO:0055012ventricular cardiac muscle cell differentiation
BPIEAGO:0060038cardiac muscle cell proliferation
BPIEAGO:0060528secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
BPIEAGO:0060687regulation of branching involved in prostate gland morphogenesis
BPIEAGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001972retinoic acid binding
MFIDAGO:0003677DNA binding
MFIMPGO:0003690double-stranded DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFTASGO:0003708retinoic acid receptor activity
MFTASGO:0003713transcription coactivator activity
MFIDAGO:0004879nuclear receptor activity
MFIEAGO:00048869-cis retinoic acid receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008270zinc ion binding
MFIPIGO:0016922nuclear receptor binding
MFIPIGO:0019899enzyme binding
MFIEAGO:0031490chromatin DNA binding
MFIDAGO:0042277peptide binding
MFIPIGO:0042809vitamin D receptor binding
MFIDAGO:0043565sequence-specific DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044323retinoic acid-responsive element binding
MFIDAGO:0046982protein heterodimerization activity
MFIDAGO:0050692DBD domain binding
MFIDAGO:0050693LBD domain binding
MFIDAGO:0070644vitamin D response element binding

Gene expression in normal tissue: RXRA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RXRA


DatabasePathway IDPathway Des.
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartappargpathwayrole of ppar-gamma coactivators in obesity and thermogenesis
biocartapparpathwaybasic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
biocartararpathwaydegradation of the rar and rxr by the proteasome
biocartararrxrpathwaynuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
biocartavobesitypathwayvisceral fat deposits and the metabolic syndrome
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1368082RORA activates gene expression
reactomeR-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-159418Recycling of bile acids and salts
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-192105Synthesis of bile acids and bile salts
reactomeR-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
reactomeR-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterol
reactomeR-HSA-194068Bile acid and bile salt metabolism
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrix
reactomeR-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complex
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211976Endogenous sterols
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2151201Transcriptional activation of mitochondrial biogenesis
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-70268Pyruvate metabolism
reactomeR-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycle
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-8978868Fatty acid metabolism
reactomeR-HSA-9006931Signaling by Nuclear Receptors
wikipathwaysWP1531Vitamin D Metabolism
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP236Adipogenesis
wikipathwaysWP2874Liver X Receptor Pathway
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP2878PPAR Alpha Pathway
wikipathwaysWP2879Farnesoid X Receptor Pathway
wikipathwaysWP2880Glucocorticoid Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP716Vitamin A and Carotenoid Metabolism
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidar_tf_pathwayRegulation of Androgen receptor activity
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
netpathPathway_TNFalphaTNFalpha
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04976Bile secretion - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD150RITA3
iGMDRD512nutlin 34
iGMDRD177Teniposide2
iGMDRD351GW843682X4
iGMDRD267Oligomycin A1
iGMDRD415LE-1352
iGMDRD705Nakiterpiosin3
iGMDRD121GMX17781
iGMDRD137Indisulam2
iGMDRD103SN-383
iGMDRD353PD03259014
iGMDRD781Sirolimus4
iGMDRD494Neopeltolide4
iGMDRD772BRD47702
iGMDRD420Leucascandrolide A2
iGMDRD126Tipifarnib3
iGMDRD634SCHEMBL26080414
iGMDRD375GW-4058332
iGMDRD280CYTOCHALASIN B3
iGMDRD466Chaetocin2
iGMDRD679Bistramide A6
iGMDRD297Austocystin D3
iGMDRD152179324-69-73
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD782DC-45-A22
iGMDRD171Pemetrexed3
iGMDRD451Serdemetan3
iGMDRD369TGX-1153
iGMDRD577BIX012944
iGMDRD188Piperlongumine1
iGMDRD100Zebularine2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RXRA

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