CLSTN1
Summary: This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calsyntenin 1 | MIM:611321 | Ensembl:ENSG00000171603 | HGNC:HGNC:17447 | PA38238 | 1p36.22 |
GO terms in CLSTN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0050806 | positive regulation of synaptic transmission |
| BP | IEA | GO:0050806 | positive regulation of synaptic transmission |
| BP | IBA | GO:0051965 | positive regulation of synapse assembly |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0009986 | cell surface |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0042995 | cell projection |
| CC | IBA | GO:0045211 | postsynaptic membrane |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| MF | IDA | GO:0001540 | amyloid-beta binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019894 | kinesin binding |
| MF | IPI | GO:0042988 | X11-like protein binding |
Gene expression in normal tissue: CLSTN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLSTN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD505 | Pevonedistat | 11 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD137 | Indisulam | 7 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD150 | RITA | 10 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD936 | JW-7-52-1 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD427 | ABT737 | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLSTN1
CLASSFICATION
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