CLSTN1


Summary: This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calsyntenin 1MIM:611321Ensembl:ENSG00000171603HGNC:HGNC:17447PA382381p36.22

GO terms in CLSTN1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001558regulation of cell growth
BPTASGO:0007155cell adhesion
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0050806positive regulation of synaptic transmission
BPIEAGO:0050806positive regulation of synaptic transmission
BPIBAGO:0051965positive regulation of synapse assembly
BPIEAGO:0051965positive regulation of synapse assembly
CCIEAGO:0000139Golgi membrane
CCIEAGO:0005576extracellular region
CCIEAGO:0005634nucleus
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0009986cell surface
CCIEAGO:0009986cell surface
CCIEAGO:0014069postsynaptic density
CCIEAGO:0016021integral component of membrane
CCIEAGO:0030054cell junction
CCIEAGO:0042995cell projection
CCIBAGO:0045211postsynaptic membrane
CCIEAGO:0045211postsynaptic membrane
MFIDAGO:0001540amyloid-beta binding
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIPIGO:0019894kinesin binding
MFIPIGO:0042988X11-like protein binding

Gene expression in normal tissue: CLSTN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLSTN1


DatabasePathway IDPathway Des.
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck602
iGMDRD286Nsc 6328392
iGMDRD505Pevonedistat11
iGMDRD202Curcumin2
iGMDRD137Indisulam7
iGMDRD434BMS-5369242
iGMDRD351GW843682X2
iGMDRD237ABT-7512
iGMDRD211(1S,3R)-RSL32
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine3
iGMDRD512nutlin 33
iGMDRD79Gemcitabine2
iGMDRD532Olaparib3
iGMDRD150RITA10
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD424Tamatinib1
iGMDRD577BIX012942
iGMDRD562Navitoclax3
iGMDRD188Piperlongumine2
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3
iGMDRD444Tivantinib1
iGMDRD64Parbendazole2
iGMDRD255SB2250024
iGMDRD138PX 122
iGMDRD318PAC-12
iGMDRD870BRD636101
iGMDRD639YK 4-2793
iGMDRD61Kinetin riboside3
iGMDRD193Fqi13
iGMDRD446LY 21832404
iGMDRD936JW-7-52-11
iGMDRD634SCHEMBL26080415
iGMDRD889Compound 7d-cis5
iGMDRD433Lexibulin2
iGMDRD427ABT7377

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLSTN1

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