DDR2
Summary: This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| discoidin domain receptor tyrosine kinase 2 | MIM:191311 | Ensembl:ENSG00000162733 | HGNC:HGNC:2731 | PA27196 | 1q23.3 |
GO terms in DDR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IEA | GO:0001503 | ossification |
| BP | ISS | GO:0003416 | endochondral bone growth |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | TAS | GO:0010715 | regulation of extracellular matrix disassembly |
| BP | ISS | GO:0010763 | positive regulation of fibroblast migration |
| BP | TAS | GO:0010763 | positive regulation of fibroblast migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | ISS | GO:0030199 | collagen fibril organization |
| BP | IMP | GO:0030500 | regulation of bone mineralization |
| BP | ISS | GO:0031214 | biomineral tissue development |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | ISS | GO:0035988 | chondrocyte proliferation |
| BP | TAS | GO:0035988 | chondrocyte proliferation |
| BP | IDA | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IMP | GO:0045860 | positive regulation of protein kinase activity |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IMP | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0090091 | positive regulation of extracellular matrix disassembly |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005518 | collagen binding |
| MF | IDA | GO:0005518 | collagen binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IBA | GO:0038062 | protein tyrosine kinase collagen receptor activity |
| MF | IDA | GO:0038062 | protein tyrosine kinase collagen receptor activity |
Gene expression in normal tissue: DDR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| wikipathways | WP474 | Endochondral Ossification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD239 | Dasatinib | 15 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD131 | Erlotinib | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDR2
CLASSFICATION
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