HIPK2


Summary: This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeodomain interacting protein kinase 2MIM:606868Ensembl:ENSG00000064393HGNC:HGNC:14402PA292917q34

GO terms in HIPK2


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0001102RNA polymerase II activating transcription factor binding
MFISSGO:0003713transcription coactivator activity
MFIDAGO:0003714transcription corepressor activity
MFIDAGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0046332SMAD binding
MFIPIGO:0046790virion binding
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001654eye development
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BPIEAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007224smoothened signaling pathway
BPIEAGO:0007628adult walking behavior
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009952anterior/posterior pattern specification
BPIEAGO:0010842retina layer formation
BPISSGO:0018105peptidyl-serine phosphorylation
BPISSGO:0018107peptidyl-threonine phosphorylation
BPNASGO:0019048modulation by virus of host morphology or physiology
BPIEAGO:0030182neuron differentiation
BPISSGO:0030218erythrocyte differentiation
BPIMPGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIMPGO:0030514negative regulation of BMP signaling pathway
BPTASGO:0030578PML body organization
BPISSGO:0032092positive regulation of protein binding
BPTASGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIEAGO:0043388positive regulation of DNA binding
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIDAGO:0045766positive regulation of angiogenesis
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0046330positive regulation of JNK cascade
BPIEAGO:0048596embryonic camera-type eye morphogenesis
BPIEAGO:0050882voluntary musculoskeletal movement
BPISSGO:0051091positive regulation of DNA-binding transcription factor activity
BPTASGO:0051726regulation of cell cycle
BPIEAGO:0060059embryonic retina morphogenesis in camera-type eye
BPIEAGO:0060235lens induction in camera-type eye
BPIDAGO:0060395SMAD protein signal transduction
BPIEAGO:0061072iris morphogenesis
BPTASGO:0071456cellular response to hypoxia
BPNASGO:0097193intrinsic apoptotic signaling pathway
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIMPGO:2000059negative regulation of ubiquitin-dependent protein catabolic process
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCISSGO:0005737cytoplasm
CCIDAGO:0016604nuclear body
CCTASGO:0016604nuclear body
CCIDAGO:0016605PML body
CCISSGO:0090575RNA polymerase II transcription factor complex

Gene expression in normal tissue: HIPK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIPK2


DatabasePathway IDPathway Des.
wikipathwaysWP3938miR-222 in Exercise-Induced Cardiac Growth
kegghsa04218Cellular senescence - Homo sapiens (human)
pidcmyb_pathwayC-MYB transcription factor network
pidp53regulationpathwayp53 pathway
netpathPathway_EGFR1EGFR1
reactomeR-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578768Physiological factors
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD427ABT7375
iGMDRD670ML 2103
iGMDRD781Sirolimus4
iGMDRD433Lexibulin3
iGMDRD126Tipifarnib3
iGMDRD889Compound 7d-cis5
iGMDRD280CYTOCHALASIN B8
iGMDRD394BX-7953
iGMDRD446LY 21832401
iGMDRD193Fqi16
iGMDRD171Pemetrexed3
iGMDRD294Batimastat3
iGMDRD318PAC-12
iGMDRD8024-methylfasudil3
iGMDRD64Parbendazole6
iGMDRD524ISX-91
iGMDRD598QS-113
iGMDRD23Gossypol4
iGMDRD356PNU-746543
iGMDRD730Kahalalide F3
iGMDRD188Piperlongumine2
iGMDRD780PP-303
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD150RITA2
iGMDRD79Gemcitabine2
iGMDRD405PIK-752
iGMDRD248BRD43543
iGMDRD148Pifithrin-mu2
iGMDRD512nutlin 36
iGMDRD211(1S,3R)-RSL33
iGMDRD237ABT-7515
iGMDRD314Tanespimycin1
iGMDRD351GW843682X2
iGMDRD137Indisulam1
iGMDRD202Curcumin1
iGMDRD158NSC1415403
iGMDRD552AZD-17751
iGMDRD886Compound 1541A2
iGMDRD286Nsc 6328395
iGMDRD329Merck602

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIPK2

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