ISG15


Summary: The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ISG15 ubiquitin-like modifierMIM:147571Ensembl:ENSG00000187608HGNC:HGNC:4053PA284651p36.33

GO terms in ISG15


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0031386protein tag
BPIEAGO:0016032viral process
BPIEAGO:0019941modification-dependent protein catabolic process
BPTASGO:0019985translesion synthesis
BPISSGO:0030501positive regulation of bone mineralization
BPIDAGO:0031397negative regulation of protein ubiquitination
BPIDAGO:0032020ISG15-protein conjugation
BPIMPGO:0032020ISG15-protein conjugation
BPTASGO:0032480negative regulation of type I interferon production
BPIMPGO:0032649regulation of interferon-gamma production
BPIDAGO:0034340response to type I interferon
BPIMPGO:0042742defense response to bacterium
BPIMPGO:0045071negative regulation of viral genome replication
BPIEAGO:0045648positive regulation of erythrocyte differentiation
BPIMPGO:0051607defense response to virus
BPTASGO:0060337type I interferon signaling pathway
CCIDAGO:0005576extracellular region
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol

Gene expression in normal tissue: ISG15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ISG15


DatabasePathway IDPathway Des.
reactomeR-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168253Host Interactions with Influenza Factors
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168256Immune System
reactomeR-HSA-168276NS1 Mediated Effects on Host Pathways
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-5656169Termination of translesion DNA synthesis
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-73893DNA Damage Bypass
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-936440Negative regulators of DDX58/IFIH1 signaling
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP619Type II interferon signaling (IFNG)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD6AM-5803
iGMDRD267Oligomycin A4
iGMDRD271Brefeldin A3
iGMDRD137Indisulam4
iGMDRD202Curcumin6
iGMDRD246NPC263
iGMDRD82Quiflapon3
iGMDRD414MST-3121
iGMDRD871BRD63686
iGMDRD872BRD71373
iGMDRD329Merck603
iGMDRD560MK-22063
iGMDRD405PIK-756
iGMDRD330BRD41326
iGMDRD307Manumycin A3
iGMDRD248BRD43544
iGMDRD782DC-45-A21
iGMDRD441TW 376
iGMDRD52Rotenone6
iGMDRD870BRD636103
iGMDRD474Avrainvillamide5
iGMDRD23Gossypol5
iGMDRD524ISX-93
iGMDRD577BIX012944
iGMDRD888Compound 443
iGMDRD562Navitoclax1
iGMDRD780PP-303
iGMDRD427ABT7376
iGMDRD494Neopeltolide3
iGMDRD554CHEMBL14341373
iGMDRD599Salermide3
iGMDRD420Leucascandrolide A5
iGMDRD466Chaetocin3
iGMDRD718Pyrvinium pamoate3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ISG15

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