TNFRSF9
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 9 | MIM:602250 | Ensembl:ENSG00000049249 | HGNC:HGNC:11924 | PA36617 | 1p36.23 |
GO terms in TNFRSF9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0070207 | protein homotrimerization |
| BP | IEA | GO:2001180 | negative regulation of interleukin-10 secretion |
| BP | IEA | GO:2001183 | negative regulation of interleukin-12 secretion |
| CC | IEA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| MF | IEA | GO:0019955 | cytokine binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: TNFRSF9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD123 | Isoevodiamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF9
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