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TPO

Summary: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
thyroid peroxidase	MIM:606765	Ensembl:ENSG00000115705	HGNC:HGNC:12015	PA36694	2p25.3

Gene Categories:

CELL SURFACE DRUGGABLE GENOME

GO terms in TPO

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004447	iodide peroxidase activity
MF	IBA	GO:0004601	peroxidase activity
MF	TAS	GO:0004601	peroxidase activity
MF	IEA	GO:0005509	calcium ion binding
MF	IEA	GO:0020037	heme binding
CC	HDA	GO:0005615	extracellular space
CC	IBA	GO:0005615	extracellular space
CC	TAS	GO:0005886	plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0009986	cell surface
BP	IEA	GO:0006590	thyroid hormone generation
BP	TAS	GO:0006590	thyroid hormone generation
BP	IEA	GO:0006979	response to oxidative stress
BP	IDA	GO:0035162	embryonic hemopoiesis
BP	IEA	GO:0042446	hormone biosynthetic process
BP	IEA	GO:0042744	hydrogen peroxide catabolic process
BP	IEA	GO:0055114	oxidation-reduction process
BP	IEA	GO:0098869	cellular oxidant detoxification

Gene expression in normal tissue: TPO

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TPO

Database	Pathway ID	Pathway Des.
kegg	hsa00350	Tyrosine metabolism - Homo sapiens (human)
kegg	hsa04918	Thyroid hormone synthesis - Homo sapiens (human)
kegg	hsa05320	Autoimmune thyroid disease - Homo sapiens (human)
humancyc	PWY-6241	thyroid hormone biosynthesis
smpdb	SMP00716	Thyroid hormone synthesis
wikipathways	WP1981	Thyroxine (Thyroid Hormone) Production
wikipathways	WP2848	Differentiation Pathway
wikipathways	WP2849	Hematopoietic Stem Cell Differentiation
wikipathways	WP3892	Development of pulmonary dendritic cells and macrophage subsets
wikipathways	WP3925	Amino Acid metabolism
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-209776	Amine-derived hormones
reactome	R-HSA-209968	Thyroxine biosynthesis
reactome	R-HSA-71291	Metabolism of amino acids and derivatives

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD577	BIX01294	5
iGMDRD398	Sepantronium	2
iGMDRD780	PP-30	2
iGMDRD100	Zebularine	5
iGMDRD188	Piperlongumine	4
iGMDRD74	Idarubicin	3
iGMDRD356	PNU-74654	2
iGMDRD524	ISX-9	2
iGMDRD64	Parbendazole	4
iGMDRD513	BML-259	2
iGMDRD187	BRD9876	1
iGMDRD193	Fqi1	1
iGMDRD446	LY 2183240	6
iGMDRD297	Austocystin D	1
iGMDRD280	CYTOCHALASIN B	6
iGMDRD394	BX-795	3
iGMDRD889	Compound 7d-cis	5
iGMDRD1008	SR-II-138A	1
iGMDRD433	Lexibulin	2
iGMDRD781	Sirolimus	6
iGMDRD144	NSC95397	2
iGMDRD871	BRD6368	2
iGMDRD872	BRD7137	2
iGMDRD42	Vorinostat	2
iGMDRD300	Tozasertib	6
iGMDRD886	Compound 1541A	3
iGMDRD137	Indisulam	6
iGMDRD77	Itraconazole	3
iGMDRD705	Nakiterpiosin	2
iGMDRD351	GW843682X	6
iGMDRD237	ABT-751	3
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD123	Isoevodiamine	5
iGMDRD345	Compound 10b [PMID: 11504634]	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TPO

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.