TPO


Summary: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thyroid peroxidaseMIM:606765Ensembl:ENSG00000115705HGNC:HGNC:12015PA366942p25.3

GO terms in TPO


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004447iodide peroxidase activity
MFIBAGO:0004601peroxidase activity
MFTASGO:0004601peroxidase activity
MFIEAGO:0005509calcium ion binding
MFIEAGO:0020037heme binding
CCHDAGO:0005615extracellular space
CCIBAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0009986cell surface
BPIEAGO:0006590thyroid hormone generation
BPTASGO:0006590thyroid hormone generation
BPIEAGO:0006979response to oxidative stress
BPIDAGO:0035162embryonic hemopoiesis
BPIEAGO:0042446hormone biosynthetic process
BPIEAGO:0042744hydrogen peroxide catabolic process
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0098869cellular oxidant detoxification

Gene expression in normal tissue: TPO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TPO


DatabasePathway IDPathway Des.
kegghsa00350Tyrosine metabolism - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
humancycPWY-6241thyroid hormone biosynthesis
smpdbSMP00716Thyroid hormone synthesis
wikipathwaysWP1981Thyroxine (Thyroid Hormone) Production
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP3892Development of pulmonary dendritic cells and macrophage subsets
wikipathwaysWP3925Amino Acid metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-209776Amine-derived hormones
reactomeR-HSA-209968Thyroxine biosynthesis
reactomeR-HSA-71291Metabolism of amino acids and derivatives

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD577BIX012945
iGMDRD398Sepantronium2
iGMDRD780PP-302
iGMDRD100Zebularine5
iGMDRD188Piperlongumine4
iGMDRD74Idarubicin3
iGMDRD356PNU-746542
iGMDRD524ISX-92
iGMDRD64Parbendazole4
iGMDRD513BML-2592
iGMDRD187BRD98761
iGMDRD193Fqi11
iGMDRD446LY 21832406
iGMDRD297Austocystin D1
iGMDRD280CYTOCHALASIN B6
iGMDRD394BX-7953
iGMDRD889Compound 7d-cis5
iGMDRD1008SR-II-138A1
iGMDRD433Lexibulin2
iGMDRD781Sirolimus6
iGMDRD144NSC953972
iGMDRD871BRD63682
iGMDRD872BRD71372
iGMDRD42Vorinostat2
iGMDRD300Tozasertib6
iGMDRD886Compound 1541A3
iGMDRD137Indisulam6
iGMDRD77Itraconazole3
iGMDRD705Nakiterpiosin2
iGMDRD351GW843682X6
iGMDRD237ABT-7513
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD123Isoevodiamine5
iGMDRD345Compound 10b [PMID: 11504634]5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TPO

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