TPO
Summary: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
thyroid peroxidase | MIM:606765 | Ensembl:ENSG00000115705 | HGNC:HGNC:12015 | PA36694 | 2p25.3 |
GO terms in TPO
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0004447 | iodide peroxidase activity |
MF | IBA | GO:0004601 | peroxidase activity |
MF | TAS | GO:0004601 | peroxidase activity |
MF | IEA | GO:0005509 | calcium ion binding |
MF | IEA | GO:0020037 | heme binding |
CC | HDA | GO:0005615 | extracellular space |
CC | IBA | GO:0005615 | extracellular space |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | IEA | GO:0009986 | cell surface |
BP | IEA | GO:0006590 | thyroid hormone generation |
BP | TAS | GO:0006590 | thyroid hormone generation |
BP | IEA | GO:0006979 | response to oxidative stress |
BP | IDA | GO:0035162 | embryonic hemopoiesis |
BP | IEA | GO:0042446 | hormone biosynthetic process |
BP | IEA | GO:0042744 | hydrogen peroxide catabolic process |
BP | IEA | GO:0055114 | oxidation-reduction process |
BP | IEA | GO:0098869 | cellular oxidant detoxification |
Gene expression in normal tissue: TPO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TPO
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
humancyc | PWY-6241 | thyroid hormone biosynthesis |
smpdb | SMP00716 | Thyroid hormone synthesis |
wikipathways | WP1981 | Thyroxine (Thyroid Hormone) Production |
wikipathways | WP2848 | Differentiation Pathway |
wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
wikipathways | WP3892 | Development of pulmonary dendritic cells and macrophage subsets |
wikipathways | WP3925 | Amino Acid metabolism |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-209776 | Amine-derived hormones |
reactome | R-HSA-209968 | Thyroxine biosynthesis |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD577 | BIX01294 | 5 |
iGMDRD398 | Sepantronium | 2 |
iGMDRD780 | PP-30 | 2 |
iGMDRD100 | Zebularine | 5 |
iGMDRD188 | Piperlongumine | 4 |
iGMDRD74 | Idarubicin | 3 |
iGMDRD356 | PNU-74654 | 2 |
iGMDRD524 | ISX-9 | 2 |
iGMDRD64 | Parbendazole | 4 |
iGMDRD513 | BML-259 | 2 |
iGMDRD187 | BRD9876 | 1 |
iGMDRD193 | Fqi1 | 1 |
iGMDRD446 | LY 2183240 | 6 |
iGMDRD297 | Austocystin D | 1 |
iGMDRD280 | CYTOCHALASIN B | 6 |
iGMDRD394 | BX-795 | 3 |
iGMDRD889 | Compound 7d-cis | 5 |
iGMDRD1008 | SR-II-138A | 1 |
iGMDRD433 | Lexibulin | 2 |
iGMDRD781 | Sirolimus | 6 |
iGMDRD144 | NSC95397 | 2 |
iGMDRD871 | BRD6368 | 2 |
iGMDRD872 | BRD7137 | 2 |
iGMDRD42 | Vorinostat | 2 |
iGMDRD300 | Tozasertib | 6 |
iGMDRD886 | Compound 1541A | 3 |
iGMDRD137 | Indisulam | 6 |
iGMDRD77 | Itraconazole | 3 |
iGMDRD705 | Nakiterpiosin | 2 |
iGMDRD351 | GW843682X | 6 |
iGMDRD237 | ABT-751 | 3 |
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
iGMDRD123 | Isoevodiamine | 5 |
iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TPO