CARD14
Summary: This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase recruitment domain family member 14 | MIM:607211 | Ensembl:ENSG00000141527 | HGNC:HGNC:16446 | PA134959119 | 17q25.3 |
GO terms in CARD14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0050700 | CARD domain binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | NAS | GO:0005886 | plasma membrane |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | NAS | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | IMP | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
Gene expression in normal tissue: CARD14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARD14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD201 | SKI II | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARD14
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