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COL14A1

Summary: This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
collagen type XIV alpha 1 chain	MIM:120324	Ensembl:ENSG00000187955	HGNC:HGNC:2191	PA26707	8q24.12

Gene Categories:

DRUGGABLE GENOME

GO terms in COL14A1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0003429	growth plate cartilage chondrocyte morphogenesis
BP	NAS	GO:0030198	extracellular matrix organization
BP	NAS	GO:0030199	collagen fibril organization
BP	NAS	GO:0098609	cell-cell adhesion
CC	HDA	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	NAS	GO:0005581	collagen trimer
CC	NAS	GO:0005596	collagen type XIV trimer
CC	HDA	GO:0005615	extracellular space
CC	TAS	GO:0005788	endoplasmic reticulum lumen
CC	NAS	GO:0031012	extracellular matrix
CC	HDA	GO:0062023	collagen-containing extracellular matrix
CC	ISS	GO:0062023	collagen-containing extracellular matrix
MF	HDA	GO:0003723	RNA binding
MF	NAS	GO:0005201	extracellular matrix structural constituent
MF	NAS	GO:0005518	collagen binding
MF	HDA	GO:0030020	extracellular matrix structural constituent conferring tensile strength
MF	ISS	GO:0030020	extracellular matrix structural constituent conferring tensile strength
MF	NAS	GO:0030674	protein binding, bridging

Gene expression in normal tissue: COL14A1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COL14A1

Database	Pathway ID	Pathway Des.
kegg	hsa04974	Protein digestion and absorption - Homo sapiens (human)
reactome	R-HSA-1442490	Collagen degradation
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474290	Collagen formation
reactome	R-HSA-1650814	Collagen biosynthesis and modifying enzymes
reactome	R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures
reactome	R-HSA-8948216	Collagen chain trimerization

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD147	Prima-1	2
iGMDRD552	AZD-1775	6
iGMDRD505	Pevonedistat	1
iGMDRD882	CIL41	3
iGMDRD213	SMR000068650	2
iGMDRD415	LE-135	1
iGMDRD105	Triptolide	5
iGMDRD705	Nakiterpiosin	6
iGMDRD121	GMX1778	3
iGMDRD137	Indisulam	4
iGMDRD511	CHEMBL399379	3
iGMDRD698	Neratinib	1
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD299	ICL 670	1
iGMDRD116	CD437	3
iGMDRD148	Pifithrin-mu	2
iGMDRD307	Manumycin A	3
iGMDRD330	BRD4132	2
iGMDRD84	Lovastatin acid	3
iGMDRD451	Serdemetan	5
iGMDRD268	Cerulenin	3
iGMDRD60	Quinoclamine	2
iGMDRD780	PP-30	6
iGMDRD887	Compound 23 citrate	3
iGMDRD188	Piperlongumine	2
iGMDRD100	Zebularine	2
iGMDRD870	BRD63610	2
iGMDRD318	PAC-1	5
iGMDRD782	DC-45-A2	5
iGMDRD260	FQI-2	1
iGMDRD613	CHEMBL258148	1
iGMDRD513	BML-259	1
iGMDRD394	BX-795	2
iGMDRD280	CYTOCHALASIN B	1
iGMDRD152	179324-69-7	3
iGMDRD61	Kinetin riboside	3
iGMDRD446	LY 2183240	7
iGMDRD781	Sirolimus	1
iGMDRD494	Neopeltolide	2
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD420	Leucascandrolide A	2
iGMDRD151	CHM-1	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COL14A1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.