GATA2


Summary: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
GATA binding protein 2MIM:137295Ensembl:ENSG00000179348HGNC:HGNC:4171PA285853q21.3

GO terms in GATA2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFIDAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001158enhancer sequence-specific DNA binding
MFIDAGO:0003682chromatin binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0070742C2H2 zinc finger domain binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001655urogenital system development
BPIEAGO:0001709cell fate determination
BPIEAGO:0001764neuron migration
BPIEAGO:0001892embryonic placenta development
BPIDAGO:0006351transcription, DNA-templated
BPIEAGO:0006909phagocytosis
BPIEAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIBAGO:0007507heart development
BPTASGO:0007596blood coagulation
BPIBAGO:0009887animal organ morphogenesis
BPIBAGO:0009888tissue development
BPIGIGO:0010628positive regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010629negative regulation of gene expression
BPIEAGO:0010725regulation of primitive erythrocyte differentiation
BPIEAGO:0021514ventral spinal cord interneuron differentiation
BPIEAGO:0021533cell differentiation in hindbrain
BPIEAGO:0021902commitment of neuronal cell to specific neuron type in forebrain
BPIEAGO:0021954central nervous system neuron development
BPIEAGO:0021983pituitary gland development
BPIEAGO:0033993response to lipid
BPIEAGO:0035019somatic stem cell population maintenance
BPIEAGO:0035065regulation of histone acetylation
BPIDAGO:0035854eosinophil fate commitment
BPIEAGO:0042472inner ear morphogenesis
BPIEAGO:0043306positive regulation of mast cell degranulation
BPIBAGO:0045165cell fate commitment
BPIMPGO:0045599negative regulation of fat cell differentiation
BPIEAGO:0045648positive regulation of erythrocyte differentiation
BPIEAGO:0045650negative regulation of macrophage differentiation
BPIEAGO:0045654positive regulation of megakaryocyte differentiation
BPIEAGO:0045666positive regulation of neuron differentiation
BPIDAGO:0045746negative regulation of Notch signaling pathway
BPIDAGO:0045766positive regulation of angiogenesis
BPIMPGO:0045766positive regulation of angiogenesis
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0048468cell development
BPIEAGO:0048469cell maturation
BPIBAGO:0048565digestive tract development
BPIBAGO:0048646anatomical structure formation involved in morphogenesis
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPISSGO:0050766positive regulation of phagocytosis
BPIEAGO:0060100positive regulation of phagocytosis, engulfment
BPIEAGO:0060216definitive hemopoiesis
BPIEAGO:0060872semicircular canal development
BPIDAGO:0061614pri-miRNA transcription by RNA polymerase II
BPIMPGO:0070345negative regulation of fat cell proliferation
BPIMPGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIEAGO:0090102cochlea development
BPIEAGO:0097154GABAergic neuron differentiation
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
BPIMPGO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPIDAGO:2000178negative regulation of neural precursor cell proliferation
BPIMPGO:2000352negative regulation of endothelial cell apoptotic process
BPIEAGO:2000977regulation of forebrain neuron differentiation

Gene expression in normal tissue: GATA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA2


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
pidap1_pathwayAP-1 transcription factor network
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidhif1_tfpathwayHIF-1-alpha transcription factor network
wikipathwaysWP236Adipogenesis
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP3527Preimplantation Embryo
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP4211Transcriptional cascade regulating adipogenesis
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD82Quiflapon2
iGMDRD213SMR0000686502
iGMDRD267Oligomycin A3
iGMDRD68Paclitaxel1
iGMDRD158NSC1415401
iGMDRD137Indisulam3
iGMDRD123Isoevodiamine3
iGMDRD698Neratinib6
iGMDRD512nutlin 36
iGMDRD451Serdemetan3
iGMDRD64Parbendazole3
iGMDRD562Navitoclax3
iGMDRD888Compound 441
iGMDRD74Idarubicin4
iGMDRD399Selumetinib3
iGMDRD887Compound 23 citrate3
iGMDRD100Zebularine2
iGMDRD188Piperlongumine4
iGMDRD52Rotenone2
iGMDRD187BRD98763
iGMDRD294Batimastat3
iGMDRD782DC-45-A22
iGMDRD171Pemetrexed3
iGMDRD255SB2250022
iGMDRD260FQI-23
iGMDRD679Bistramide A3
iGMDRD466Chaetocin3
iGMDRD280CYTOCHALASIN B2
iGMDRD61Kinetin riboside6
iGMDRD152179324-69-71
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD201SKI II2
iGMDRD446LY 21832402
iGMDRD24Fasudil1
iGMDRD494Neopeltolide3
iGMDRD144NSC953972
iGMDRD1008SR-II-138A3
iGMDRD772BRD47702
iGMDRD579PF7502
iGMDRD420Leucascandrolide A3
iGMDRD151CHM-13
iGMDRD126Tipifarnib5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA2

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