NSD3


Summary: This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor binding SET domain protein 3MIM:607083Ensembl:ENSG00000147548HGNC:HGNC:12767PA373708p11.23

GO terms in NSD3


Term TypeEvidence TypeGO Term IDGO Des.
CCICGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005694chromosome
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0016571histone methylation
BPIEAGO:0034968histone lysine methylation
MFIPIGO:0005515protein binding
MFIDAGO:0018024histone-lysine N-methyltransferase activity
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: NSD3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NSD3


DatabasePathway IDPathway Des.
kegghsa00310Lysine degradation - Homo sapiens (human)
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD356PNU-746543
iGMDRD23Gossypol2
iGMDRD188Piperlongumine2
iGMDRD100Zebularine3
iGMDRD577BIX012944
iGMDRD562Navitoclax2
iGMDRD318PAC-14
iGMDRD187BRD98761
iGMDRD474Avrainvillamide3
iGMDRD8024-methylfasudil6
iGMDRD255SB2250024
iGMDRD679Bistramide A2
iGMDRD634SCHEMBL26080412
iGMDRD61Kinetin riboside7
iGMDRD193Fqi14
iGMDRD427ABT7371
iGMDRD670ML 2103
iGMDRD144NSC953974
iGMDRD779PRL-3 Inhibitor I1
iGMDRD781Sirolimus6
iGMDRD433Lexibulin3
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib7
iGMDRD353PD03259011
iGMDRD414MST-3122
iGMDRD872BRD71373
iGMDRD329Merck603
iGMDRD366PI-1033
iGMDRD434BMS-5369242
iGMDRD267Oligomycin A4
iGMDRD77Itraconazole3
iGMDRD202Curcumin1
iGMDRD901ELCPK3
iGMDRD211(1S,3R)-RSL33
iGMDRD123Isoevodiamine3
iGMDRD341Triacsin c7
iGMDRD57Chloropentafluorobenzene2
iGMDRD150RITA8
iGMDRD405PIK-753

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NSD3

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