TIAM1
Summary: This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
T cell lymphoma invasion and metastasis 1 | MIM:600687 | Ensembl:ENSG00000156299 | HGNC:HGNC:11805 | PA36514 | 21q22.11 |
GO terms in TIAM1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IEA | GO:0005634 | nucleus |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0005874 | microtubule |
CC | IDA | GO:0005886 | plasma membrane |
CC | IDA | GO:0005911 | cell-cell junction |
CC | IEA | GO:0014069 | postsynaptic density |
CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
CC | IEA | GO:0032587 | ruffle membrane |
CC | IEA | GO:0043025 | neuronal cell body |
CC | IEA | GO:0043197 | dendritic spine |
CC | IDA | GO:0044291 | cell-cell contact zone |
CC | IEA | GO:0044295 | axonal growth cone |
CC | IEA | GO:0044304 | main axon |
BP | IEA | GO:0003300 | cardiac muscle hypertrophy |
BP | IEA | GO:0006915 | apoptotic process |
BP | IMP | GO:0007160 | cell-matrix adhesion |
BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
BP | IDA | GO:0008284 | positive regulation of cell proliferation |
BP | IDA | GO:0010717 | regulation of epithelial to mesenchymal transition |
BP | NAS | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
BP | IMP | GO:0016477 | cell migration |
BP | IMP | GO:0016601 | Rac protein signal transduction |
BP | IDA | GO:0030335 | positive regulation of cell migration |
BP | IDA | GO:0032092 | positive regulation of protein binding |
BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
BP | IEA | GO:0042220 | response to cocaine |
BP | TAS | GO:0043065 | positive regulation of apoptotic process |
BP | IEA | GO:0043507 | positive regulation of JUN kinase activity |
BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
BP | IEA | GO:0050772 | positive regulation of axonogenesis |
BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
BP | NAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
BP | IEA | GO:0061003 | positive regulation of dendritic spine morphogenesis |
BP | IEA | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
BP | IEA | GO:0070372 | regulation of ERK1 and ERK2 cascade |
BP | IEA | GO:0072657 | protein localization to membrane |
BP | IDA | GO:0090630 | activation of GTPase activity |
BP | IEA | GO:0098989 | NMDA selective glutamate receptor signaling pathway |
BP | IEA | GO:1904268 | positive regulation of Schwann cell chemotaxis |
BP | ISS | GO:1904338 | regulation of dopaminergic neuron differentiation |
BP | IEA | GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton |
BP | IEA | GO:1990138 | neuron projection extension |
BP | ISS | GO:2000050 | regulation of non-canonical Wnt signaling pathway |
MF | EXP | GO:0005085 | guanyl-nucleotide exchange factor activity |
MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008017 | microtubule binding |
MF | IEA | GO:0008289 | lipid binding |
MF | IPI | GO:0019900 | kinase binding |
MF | IDA | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
MF | IMP | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
MF | IEA | GO:0030971 | receptor tyrosine kinase binding |
Gene expression in normal tissue: TIAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIAM1
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
wikipathways | WP3929 | Chemokine signaling pathway |
wikipathways | WP4180 | Ebola Virus Pathway on Host |
wikipathways | WP4217 | Ebola Virus Pathway on Host |
wikipathways | WP4223 | Ras Signaling |
pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
pid | arf6downstreampathway | Arf6 downstream pathway |
pid | cdc42_pathway | CDC42 signaling events |
pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
pid | epha2_fwdpathway | EPHA2 forward signaling |
pid | ephrinbrevpathway | Ephrin B reverse signaling |
pid | lysophospholipid_pathway | LPA receptor mediated events |
pid | rac1_reg_pathway | Regulation of RAC1 activity |
pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
kegg | hsa04530 | Tight junction - Homo sapiens (human) |
kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-166520 | Signaling by NTRKs |
reactome | R-HSA-193648 | NRAGE signals death through JNK |
reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
reactome | R-HSA-194840 | Rho GTPase cycle |
reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-388396 | GPCR downstream signalling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
reactome | R-HSA-416482 | G alpha (12/13) signalling events |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-73887 | Death Receptor Signalling |
reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
reactome | R-HSA-9032845 | Activated NTRK2 signals through CDK5 |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD398 | Sepantronium | 2 |
iGMDRD562 | Navitoclax | 1 |
iGMDRD780 | PP-30 | 1 |
iGMDRD577 | BIX01294 | 2 |
iGMDRD506 | Fedratinib | 2 |
iGMDRD64 | Parbendazole | 2 |
iGMDRD60 | Quinoclamine | 3 |
iGMDRD474 | Avrainvillamide | 1 |
iGMDRD138 | PX 12 | 1 |
iGMDRD207 | Capsaicin | 2 |
iGMDRD52 | Rotenone | 2 |
iGMDRD226 | ML006 | 2 |
iGMDRD318 | PAC-1 | 2 |
iGMDRD152 | 179324-69-7 | 4 |
iGMDRD61 | Kinetin riboside | 7 |
iGMDRD679 | Bistramide A | 2 |
iGMDRD280 | CYTOCHALASIN B | 3 |
iGMDRD394 | BX-795 | 1 |
iGMDRD375 | GW-405833 | 2 |
iGMDRD420 | Leucascandrolide A | 3 |
iGMDRD599 | Salermide | 3 |
iGMDRD144 | NSC95397 | 2 |
iGMDRD427 | ABT737 | 2 |
iGMDRD494 | Neopeltolide | 2 |
iGMDRD329 | Merck60 | 2 |
iGMDRD263 | AACOCF3 | 4 |
iGMDRD552 | AZD-1775 | 4 |
iGMDRD42 | Vorinostat | 4 |
iGMDRD202 | Curcumin | 3 |
iGMDRD121 | GMX1778 | 2 |
iGMDRD251 | ML162 | 2 |
iGMDRD5 | Tyrphostin AG 1478 | 4 |
iGMDRD289 | Parthenolide | 4 |
iGMDRD481 | Dactolisib | 2 |
iGMDRD698 | Neratinib | 4 |
iGMDRD901 | ELCPK | 2 |
iGMDRD945 | ML214 | 1 |
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
iGMDRD511 | CHEMBL399379 | 2 |
iGMDRD486 | Tosedostat | 3 |
iGMDRD330 | BRD4132 | 2 |
iGMDRD522 | ML-030 | 3 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in TIAM1