TNFRSF11B


Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TNF receptor superfamily member 11bMIM:602643Ensembl:ENSG00000164761HGNC:HGNC:11909PA366028q24.12

GO terms in TNFRSF11B


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
BPTASGO:0001501skeletal system development
BPTASGO:0007165signal transduction
BPIEAGO:0007584response to nutrient
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0030198extracellular matrix organization
BPIEAGO:0032026response to magnesium ion
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIEAGO:0042489negative regulation of odontogenesis of dentin-containing tooth
BPIEAGO:0042493response to drug
BPIEAGO:0043627response to estrogen
BPIEAGO:0045779negative regulation of bone resorption
BPIEAGO:0046685response to arsenic-containing substance
MFTASGO:0005125cytokine activity
MFIPIGO:0005515protein binding
MFTASGO:0038023signaling receptor activity

Gene expression in normal tissue: TNFRSF11B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF11B


DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
wikipathwaysWP12Osteoclast Signaling
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP322Osteoblast Signaling
wikipathwaysWP727Monoamine Transport
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 33
iGMDRD150RITA4
iGMDRD116CD4372
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD494Neopeltolide1
iGMDRD781Sirolimus2
iGMDRD211(1S,3R)-RSL32
iGMDRD297Austocystin D5
iGMDRD123Isoevodiamine3
iGMDRD177Teniposide2
iGMDRD280CYTOCHALASIN B6
iGMDRD466Chaetocin4
iGMDRD375GW-4058332
iGMDRD634SCHEMBL26080412
iGMDRD945ML2143
iGMDRD105Triptolide3
iGMDRD434BMS-5369242
iGMDRD782DC-45-A22
iGMDRD171Pemetrexed4
iGMDRD415LE-1352
iGMDRD414MST-3122
iGMDRD286Nsc 6328393
iGMDRD188Piperlongumine2
iGMDRD577BIX012942
iGMDRD888Compound 443
iGMDRD366PI-1032
iGMDRD505Pevonedistat2
iGMDRD246NPC264
iGMDRD64Parbendazole5
iGMDRD263AACOCF32
iGMDRD356PNU-746542

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF11B

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