ADAMTS18
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase with thrombospondin type 1 motif 18 | MIM:607512 | Ensembl:ENSG00000140873 | HGNC:HGNC:17110 | PA24544 | 16q23.1 |
GO terms in ADAMTS18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IEA | GO:0005576 | extracellular region |
| BP | IMP | GO:0001654 | eye development |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IDA | GO:0090331 | negative regulation of platelet aggregation |
Gene expression in normal tissue: ADAMTS18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAMTS18
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5083635 | Defective B3GALTL causes Peters-plus syndrome (PpS) |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD679 | Bistramide A | 7 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD888 | Compound 44 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAMTS18
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