AMHR2


Summary: This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
anti-Mullerian hormone receptor type 2MIM:600956Ensembl:ENSG00000135409HGNC:HGNC:465PA2477012q13.13

GO terms in AMHR2


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIBAGO:0043235receptor complex
BPNASGO:0001880Mullerian duct regression
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007179transforming growth factor beta receptor signaling pathway
BPIBAGO:0007389pattern specification process
BPIBAGO:0007548sex differentiation
BPISSGO:0007548sex differentiation
BPTASGO:0007548sex differentiation
BPIEAGO:0008584male gonad development
BPIEAGO:0008585female gonad development
BPTASGO:0030509BMP signaling pathway
BPIEAGO:1902613negative regulation of anti-Mullerian hormone signaling pathway
BPIMPGO:1990262anti-Mullerian hormone signaling pathway
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005026transforming growth factor beta receptor activity, type II
MFIEAGO:0005026transforming growth factor beta receptor activity, type II
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0019838growth factor binding
MFIPIGO:0042562hormone binding
MFIBAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0098821BMP receptor activity
MFIBAGO:1990272anti-Mullerian hormone receptor activity
MFIMPGO:1990272anti-Mullerian hormone receptor activity

Gene expression in normal tissue: AMHR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AMHR2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-9006936Signaling by TGF-beta family members
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
pidalk2pathwayALK2 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib2
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine4
iGMDRD562Navitoclax2
iGMDRD398Sepantronium2
iGMDRD506Fedratinib2
iGMDRD64Parbendazole3
iGMDRD524ISX-93
iGMDRD630ML2033
iGMDRD451Serdemetan2
iGMDRD23Gossypol2
iGMDRD356PNU-746541
iGMDRD270Ciclosporin3
iGMDRD247Blebbistatin3
iGMDRD260FQI-21
iGMDRD8024-methylfasudil1
iGMDRD294Batimastat1
iGMDRD446LY 21832403
iGMDRD61Kinetin riboside7
iGMDRD193Fqi13
iGMDRD210AC556491
iGMDRD554CHEMBL14341372
iGMDRD151CHM-12
iGMDRD126Tipifarnib2
iGMDRD1008SR-II-138A2
iGMDRD387CHIR-990211
iGMDRD670ML 2101
iGMDRD427ABT7372
iGMDRD546BMS-7548072
iGMDRD414MST-3122
iGMDRD662JQ-12
iGMDRD329Merck602
iGMDRD246NPC262
iGMDRD505Pevonedistat6
iGMDRD300Tozasertib2
iGMDRD121GMX17783
iGMDRD271Brefeldin A2
iGMDRD137Indisulam2
iGMDRD5Tyrphostin AG 14782
iGMDRD192CIL563
iGMDRD221Tamoxifen1
iGMDRD231Importazole2
iGMDRD85Ursolic acid2
iGMDRD351GW843682X1
iGMDRD84Lovastatin acid2
iGMDRD116CD4371
iGMDRD150RITA3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AMHR2

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