ATP13A5


Summary: This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein phosphatase, which dephosphorylates the P-domain once during each catalytic cycle. [provided by RefSeq, Jul 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATPase 13A5Ensembl:ENSG00000187527HGNC:HGNC:31789PA1349520383q29

GO terms in ATP13A5


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005524ATP binding
MFTASGO:0019829cation-transporting ATPase activity
MFIEAGO:0046872metal ion binding
BPIBAGO:0006874cellular calcium ion homeostasis
BPTASGO:0034220ion transmembrane transport
BPIEAGO:0070588calcium ion transmembrane transport
BPIEAGO:0099132ATP hydrolysis coupled cation transmembrane transport
CCTASGO:0005886plasma membrane

Gene expression in normal tissue: ATP13A5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP13A5


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250028
iGMDRD260FQI-23
iGMDRD138PX 124
iGMDRD318PAC-12
iGMDRD294Batimastat3
iGMDRD782DC-45-A22
iGMDRD506Fedratinib8
iGMDRD562Navitoclax3
iGMDRD188Piperlongumine3
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib2
iGMDRD23Gossypol3
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib2
iGMDRD151CHM-13
iGMDRD484Pluripotin2
iGMDRD546BMS-7548072
iGMDRD144NSC953973
iGMDRD427ABT7373
iGMDRD639YK 4-2792
iGMDRD152179324-69-72
iGMDRD446LY 21832403
iGMDRD103SN-382
iGMDRD137Indisulam1
iGMDRD202Curcumin2
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369244
iGMDRD662JQ-12
iGMDRD414MST-3122
iGMDRD248BRD43541
iGMDRD307Manumycin A2
iGMDRD116CD4373
iGMDRD698Neratinib2
iGMDRD351GW843682X6
iGMDRD219Bax channel blocker2
iGMDRD237ABT-7513
iGMDRD883CIL55A2
iGMDRD945ML2142
iGMDRD211(1S,3R)-RSL32
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP13A5

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