ATP13A5
Summary: This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein phosphatase, which dephosphorylates the P-domain once during each catalytic cycle. [provided by RefSeq, Jul 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ATPase 13A5 | Ensembl:ENSG00000187527 | HGNC:HGNC:31789 | PA134952038 | 3q29 |
GO terms in ATP13A5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0005524 | ATP binding |
MF | TAS | GO:0019829 | cation-transporting ATPase activity |
MF | IEA | GO:0046872 | metal ion binding |
BP | IBA | GO:0006874 | cellular calcium ion homeostasis |
BP | TAS | GO:0034220 | ion transmembrane transport |
BP | IEA | GO:0070588 | calcium ion transmembrane transport |
BP | IEA | GO:0099132 | ATP hydrolysis coupled cation transmembrane transport |
CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: ATP13A5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP13A5
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-936837 | Ion transport by P-type ATPases |
reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD255 | SB225002 | 8 |
iGMDRD260 | FQI-2 | 3 |
iGMDRD138 | PX 12 | 4 |
iGMDRD318 | PAC-1 | 2 |
iGMDRD294 | Batimastat | 3 |
iGMDRD782 | DC-45-A2 | 2 |
iGMDRD506 | Fedratinib | 8 |
iGMDRD562 | Navitoclax | 3 |
iGMDRD188 | Piperlongumine | 3 |
iGMDRD887 | Compound 23 citrate | 2 |
iGMDRD399 | Selumetinib | 2 |
iGMDRD23 | Gossypol | 3 |
iGMDRD889 | Compound 7d-cis | 2 |
iGMDRD126 | Tipifarnib | 2 |
iGMDRD151 | CHM-1 | 3 |
iGMDRD484 | Pluripotin | 2 |
iGMDRD546 | BMS-754807 | 2 |
iGMDRD144 | NSC95397 | 3 |
iGMDRD427 | ABT737 | 3 |
iGMDRD639 | YK 4-279 | 2 |
iGMDRD152 | 179324-69-7 | 2 |
iGMDRD446 | LY 2183240 | 3 |
iGMDRD103 | SN-38 | 2 |
iGMDRD137 | Indisulam | 1 |
iGMDRD202 | Curcumin | 2 |
iGMDRD705 | Nakiterpiosin | 3 |
iGMDRD434 | BMS-536924 | 4 |
iGMDRD662 | JQ-1 | 2 |
iGMDRD414 | MST-312 | 2 |
iGMDRD248 | BRD4354 | 1 |
iGMDRD307 | Manumycin A | 2 |
iGMDRD116 | CD437 | 3 |
iGMDRD698 | Neratinib | 2 |
iGMDRD351 | GW843682X | 6 |
iGMDRD219 | Bax channel blocker | 2 |
iGMDRD237 | ABT-751 | 3 |
iGMDRD883 | CIL55A | 2 |
iGMDRD945 | ML214 | 2 |
iGMDRD211 | (1S,3R)-RSL3 | 2 |
iGMDRD901 | ELCPK | 2 |
iGMDRD123 | Isoevodiamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP13A5