DSTYK
Summary: This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual serine/threonine and tyrosine protein kinase | MIM:612666 | Ensembl:ENSG00000133059 | HGNC:HGNC:29043 | PA164718861 | 1q32.1 |
GO terms in DSTYK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0033674 | positive regulation of kinase activity |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | IMP | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: DSTYK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DSTYK
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD6 | AM-580 | 6 |
| iGMDRD192 | CIL56 | 4 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD901 | ELCPK | 5 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD883 | CIL55A | 6 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD522 | ML-030 | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD579 | PF750 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DSTYK
CLASSFICATION
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