NCAM1


Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neural cell adhesion molecule 1MIM:116930Ensembl:ENSG00000149294HGNC:HGNC:7656PA3145911q23.2

GO terms in NCAM1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0000139Golgi membrane
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIDAGO:0009986cell surface
CCHDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031225anchored component of membrane
CCIBAGO:0043005neuron projection
CCHDAGO:0062023collagen-containing extracellular matrix
BPTASGO:0000165MAPK cascade
BPIEAGO:0007155cell adhesion
BPTASGO:0007411axon guidance
BPIEAGO:0046718viral entry into host cell
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPISSGO:0071679commissural neuron axon guidance
BPISSGO:2001260regulation of semaphorin-plexin signaling pathway
MFIEAGO:0001618virus receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity

Gene expression in normal tissue: NCAM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCAM1


DatabasePathway IDPathway Des.
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP3995Prion disease pathway
pidfgf_pathwayFGF signaling pathway
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib2
iGMDRD889Compound 7d-cis2
iGMDRD579PF7503
iGMDRD772BRD47702
iGMDRD427ABT7374
iGMDRD546BMS-7548072
iGMDRD144NSC953973
iGMDRD483SCH-5290741
iGMDRD639YK 4-2792
iGMDRD193Fqi17
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside3
iGMDRD394BX-7952
iGMDRD255SB2250022
iGMDRD782DC-45-A26
iGMDRD441TW 372
iGMDRD74Idarubicin2
iGMDRD780PP-303
iGMDRD562Navitoclax5
iGMDRD64Parbendazole2
iGMDRD23Gossypol5
iGMDRD874BRD89581
iGMDRD356PNU-746542
iGMDRD307Manumycin A1
iGMDRD512nutlin 35
iGMDRD148Pifithrin-mu2
iGMDRD116CD4371
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD522ML-0301
iGMDRD79Gemcitabine1
iGMDRD85Ursolic acid2
iGMDRD499PDMP6
iGMDRD211(1S,3R)-RSL33
iGMDRD901ELCPK2
iGMDRD177Teniposide5
iGMDRD883CIL55A4
iGMDRD103SN-385
iGMDRD137Indisulam5
iGMDRD158NSC1415403
iGMDRD105Triptolide2
iGMDRD221Tamoxifen4
iGMDRD6AM-5802
iGMDRD414MST-3123
iGMDRD286Nsc 6328392
iGMDRD263AACOCF31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCAM1

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