YWHAH


Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaMIM:113508Ensembl:ENSG00000128245HGNC:HGNC:12853PA3744222q12.3

Gene Categories:

TRANSPORTERION CHANNEL

GO terms in YWHAH


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003779actin binding
MFISSGO:0005159insulin-like growth factor receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0017080sodium channel regulator activity
MFIPIGO:0019899enzyme binding
MFISSGO:0019904protein domain specific binding
MFIPIGO:0035259glucocorticoid receptor binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0044325ion channel binding
MFIPIGO:0046982protein heterodimerization activity
BPIDAGO:0002028regulation of sodium ion transport
BPIDAGO:0006713glucocorticoid catabolic process
BPISSGO:0006886intracellular protein transport
BPHEPGO:0021762substantia nigra development
BPIDAGO:0042921glucocorticoid receptor signaling pathway
BPISSGO:0045664regulation of neuron differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0048167regulation of synaptic plasticity
BPISSGO:0050774negative regulation of dendrite morphogenesis
BPTASGO:0061024membrane organization
BPIDAGO:0086010membrane depolarization during action potential
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIDAGO:2000649regulation of sodium ion transmembrane transporter activity
CCISSGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCICGO:0014704intercalated disc
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: YWHAH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in YWHAH


DatabasePathway IDPathway Des.
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_TNFalphaTNFalpha
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
piderbb1_downstream_pathwayErbB1 downstream signaling
pidfoxopathwayFoxO family signaling
pidinsulin_glucose_pathwayInsulin-mediated glucose transport
pidlkb1_pathwayLKB1 signaling events
pidmtor_4pathwaymTOR signaling pathway
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
wikipathwaysWP179Cell Cycle
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartabadpathwayregulation of bad phosphorylation
biocartacdc25pathwaycdc25 and chk1 regulatory pathway in response to dna damage
biocartag2pathwaycell cycle: g2/m checkpoint
biocartahdacpathwaycontrol of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartamitrpathwaysignal dependent regulation of myogenesis by corepressor mitr
biocartanfatpathwaynfat and hypertrophy of the heart
biocartapgc1apathwayregulation of pgc-1a
biocartaplk3pathwayregulation of cell cycle progression by plk3
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD451Serdemetan2
iGMDRD23Gossypol4
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine3
iGMDRD369TGX-1153
iGMDRD577BIX012943
iGMDRD74Idarubicin3
iGMDRD887Compound 23 citrate2
iGMDRD730Kahalalide F3
iGMDRD399Selumetinib1
iGMDRD100Zebularine4
iGMDRD187BRD98765
iGMDRD441TW 373
iGMDRD171Pemetrexed2
iGMDRD255SB2250025
iGMDRD8024-methylfasudil1
iGMDRD634SCHEMBL26080411
iGMDRD280CYTOCHALASIN B3
iGMDRD297Austocystin D7
iGMDRD61Kinetin riboside3
iGMDRD781Sirolimus1
iGMDRD427ABT7372
iGMDRD1008SR-II-138A2
iGMDRD387CHIR-990211
iGMDRD889Compound 7d-cis2
iGMDRD42Vorinostat2
iGMDRD366PI-1034
iGMDRD662JQ-12
iGMDRD414MST-3126
iGMDRD286Nsc 6328393
iGMDRD267Oligomycin A5
iGMDRD77Itraconazole5
iGMDRD434BMS-5369242
iGMDRD221Tamoxifen3
iGMDRD121GMX17782
iGMDRD158NSC1415405
iGMDRD271Brefeldin A2
iGMDRD945ML2143
iGMDRD123Isoevodiamine3
iGMDRD57Chloropentafluorobenzene2
iGMDRD85Ursolic acid3
iGMDRD116CD4376
iGMDRD48Dexamethasone2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YWHAH

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