FOXO3


Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
forkhead box O3MIM:602681Ensembl:ENSG00000118689HGNC:HGNC:3821PA282396q21

GO terms in FOXO3


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001221transcription cofactor binding
MFIDAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008013beta-catenin binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0019901protein kinase binding
MFISSGO:0031490chromatin DNA binding
MFIMPGO:0034246mitochondrial sequence-specific DNA-binding transcription factor activity
MFIBAGO:0043565sequence-specific DNA binding
MFIDAGO:0043565sequence-specific DNA binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIMPGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0005741mitochondrial outer membrane
CCIDAGO:0005759mitochondrial matrix
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0032991protein-containing complex
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001542ovulation from ovarian follicle
BPIEAGO:0001544initiation of primordial ovarian follicle growth
BPIEAGO:0001547antral ovarian follicle growth
BPIEAGO:0001556oocyte maturation
BPISSGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPIMPGO:0006390mitochondrial transcription
BPIDAGO:0006417regulation of translation
BPIEAGO:0007568aging
BPIBAGO:0008286insulin receptor signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030330DNA damage response, signal transduction by p53 class mediator
BPIEAGO:0031667response to nutrient levels
BPIMPGO:0033209tumor necrosis factor-mediated signaling pathway
BPISSGO:0034599cellular response to oxidative stress
BPIBAGO:0042593glucose homeostasis
BPIDAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043525positive regulation of neuron apoptotic process
BPIDAGO:0045648positive regulation of erythrocyte differentiation
BPIEAGO:0045665negative regulation of neuron differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048854brain morphogenesis
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0071386cellular response to corticosterone stimulus
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:0071548response to dexamethasone
BPIEAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIEAGO:0097150neuronal stem cell population maintenance
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:1901300positive regulation of hydrogen peroxide-mediated programmed cell death
BPIEAGO:1903428positive regulation of reactive oxygen species biosynthetic process
BPIEAGO:1904646cellular response to amyloid-beta
BPIEAGO:1990090cellular response to nerve growth factor stimulus
BPIEAGO:1990785response to water-immersion restraint stress
BPIEAGO:2000177regulation of neural precursor cell proliferation
BPIEAGO:2000353positive regulation of endothelial cell apoptotic process

Gene expression in normal tissue: FOXO3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXO3


DatabasePathway IDPathway Des.
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
reactomeR-HSA-1181150Signaling by NODAL
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-198693AKT phosphorylates targets in the nucleus
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8863678Neurodegenerative Diseases
reactomeR-HSA-8863678Neurodegenerative Diseases
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
reactomeR-HSA-8952158RUNX3 regulates BCL2L11 (BIM) transcription
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9020591Interleukin-12 signaling
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3987HDAC6 interactions
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidfoxopathwayFoxO family signaling
pidhdac_classiii_pathwaySignaling events mediated by HDAC Class III
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidinsulin_pathwayInsulin Pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidp73pathwayp73 transcription factor network
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidpi3kcipathwayClass I PI3K signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
netpathPathway_BCRBCR
netpathPathway_BDNFBDNF
netpathPathway_IL-7IL-7
netpathPathway_IL2IL2
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_RAGERAGE
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22063
iGMDRD382CEP-7011
iGMDRD307Manumycin A1
iGMDRD486Tosedostat1
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD154NSC237663
iGMDRD123Isoevodiamine2
iGMDRD536PLX-47201
iGMDRD16CICLOPIROX1
iGMDRD213SMR0000686502
iGMDRD158NSC1415402
iGMDRD82Quiflapon2
iGMDRD505Pevonedistat1
iGMDRD329Merck601
iGMDRD414MST-3122
iGMDRD286Nsc 6328391
iGMDRD781Sirolimus3
iGMDRD63Camptothecin1
iGMDRD427ABT7373
iGMDRD428Brivanib1
iGMDRD772BRD47702
iGMDRD857BRD-K705115741
iGMDRD420Leucascandrolide A3
iGMDRD579PF7502
iGMDRD112Methotrexate1
iGMDRD151CHM-12
iGMDRD297Austocystin D1
iGMDRD626BRD-K331992421
iGMDRD280CYTOCHALASIN B5
iGMDRD394BX-7953
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD193Fqi12
iGMDRD446LY 21832402
iGMDRD201SKI II2
iGMDRD870BRD636101
iGMDRD52Rotenone2
iGMDRD573GSK-1904529A1
iGMDRD255SB2250026
iGMDRD493GSK269962A1
iGMDRD862BRD-K949913781
iGMDRD270Ciclosporin2
iGMDRD23Gossypol1
iGMDRD64Parbendazole1
iGMDRD888Compound 441
iGMDRD100Zebularine3
iGMDRD887Compound 23 citrate1
iGMDRD641SCH 797971
iGMDRD74Idarubicin2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXO3

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