MDM2


Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MDM2 proto-oncogeneMIM:164785Ensembl:ENSG00000135679HGNC:HGNC:6973PA3071812q15

GO terms in MDM2


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001568blood vessel development
BPIEAGO:0001974blood vessel remodeling
BPIEAGO:0002027regulation of heart rate
BPIEAGO:0003181atrioventricular valve morphogenesis
BPIEAGO:0003203endocardial cushion morphogenesis
BPIEAGO:0003281ventricular septum development
BPIEAGO:0003283atrial septum development
BPIDAGO:0006511ubiquitin-dependent protein catabolic process
BPIGIGO:0006511ubiquitin-dependent protein catabolic process
BPIMPGO:0006511ubiquitin-dependent protein catabolic process
BPIMPGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIEAGO:0007089traversing start control point of mitotic cell cycle
BPTASGO:0008284positive regulation of cell proliferation
BPIEAGO:0010039response to iron ion
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0010955negative regulation of protein processing
BPIEAGO:0010977negative regulation of neuron projection development
BPIEAGO:0016032viral process
BPIDAGO:0016567protein ubiquitination
BPTASGO:0016579protein deubiquitination
BPIEAGO:0016925protein sumoylation
BPIMPGO:0018205peptidyl-lysine modification
BPIDAGO:0031648protein destabilization
BPIMPGO:0031648protein destabilization
BPIEAGO:0032026response to magnesium ion
BPIDAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0034504protein localization to nucleus
BPTASGO:0036369transcription factor catabolic process
BPIDAGO:0042176regulation of protein catabolic process
BPIEAGO:0042220response to cocaine
BPIEAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0043278response to morphine
BPIDAGO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator
BPIDAGO:0045184establishment of protein localization
BPIEAGO:0045472response to ether
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045931positive regulation of mitotic cell cycle
BPIEPGO:0046677response to antibiotic
BPIEAGO:0046827positive regulation of protein export from nucleus
BPIEAGO:0048545response to steroid hormone
BPIMPGO:0051603proteolysis involved in cellular protein catabolic process
BPIMPGO:0051865protein autoubiquitination
BPIEAGO:0060411cardiac septum morphogenesis
BPIDAGO:0065003protein-containing complex assembly
BPIEAGO:0070301cellular response to hydrogen peroxide
BPIDAGO:0071157negative regulation of cell cycle arrest
BPIEAGO:0071301cellular response to vitamin B1
BPIEAGO:0071312cellular response to alkaloid
BPIEAGO:0071363cellular response to growth factor stimulus
BPIEAGO:0071375cellular response to peptide hormone stimulus
BPIEAGO:0071391cellular response to estrogen stimulus
BPIEPGO:0071456cellular response to hypoxia
BPIDAGO:0071480cellular response to gamma radiation
BPIEAGO:0071494cellular response to UV-C
BPIDAGO:0072717cellular response to actinomycin D
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIDAGO:1901797negative regulation of signal transduction by p53 class mediator
BPIMPGO:1902254negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
BPIEAGO:1904404response to formaldehyde
BPIEAGO:1904707positive regulation of vascular smooth muscle cell proliferation
BPIEAGO:1904754positive regulation of vascular associated smooth muscle cell migration
BPIMPGO:1990000amyloid fibril formation
BPIEAGO:1990785response to water-immersion restraint stress
CCIDAGO:0005634nucleus
CCIMPGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIMPGO:0005730nucleolus
CCIMPGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIDAGO:0016604nuclear body
CCTASGO:0030666endocytic vesicle membrane
CCIDAGO:0032991protein-containing complex
CCIMPGO:0032991protein-containing complex
CCIEAGO:0045202synapse
MFIPIGO:0002039p53 binding
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIMPGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIDAGO:00080975S rRNA binding
MFIDAGO:0008270zinc ion binding
MFIDAGO:0016874ligase activity
MFEXPGO:0019789SUMO transferase activity
MFIPIGO:0019899enzyme binding
MFIPIGO:0019904protein domain specific binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIEAGO:0033612receptor serine/threonine kinase binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0042975peroxisome proliferator activated receptor binding
MFIDAGO:0043021ribonucleoprotein complex binding
MFIPIGO:0047485protein N-terminus binding
MFIDAGO:0061630ubiquitin protein ligase activity
MFIMPGO:0061630ubiquitin protein ligase activity
MFTASGO:0061630ubiquitin protein ligase activity
MFIMPGO:0061663NEDD8 ligase activity
MFIEAGO:0097110scaffold protein binding
MFIPIGO:0097718disordered domain specific binding

Gene expression in normal tissue: MDM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MDM2


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3232118SUMOylation of transcription factors
reactomeR-HSA-3232142SUMOylation of ubiquitinylation proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6804760Regulation of TP53 Activity through Methylation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-69541Stabilization of p53
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8941858Regulation of RUNX3 expression and activity
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006925Intracellular signaling by second messengers
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartaatmpathwayatm signaling pathway
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartag2pathwaycell cycle: g2/m checkpoint
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartap53pathwayp53 signaling pathway
biocartaranbp2pathwaysumoylation by ranbp2 regulates transcriptional repression
pidar_tf_pathwayRegulation of Androgen receptor activity
pidatm_pathwayATM pathway
pidatr_pathwayATR signaling pathway
pidaurora_a_pathwayAurora A signaling
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
piderbb4_pathwayErbB4 signaling events
pidp53downstreampathwayDirect p53 effectors
pidp53regulationpathwayp53 pathway
pidp73pathwayp73 transcription factor network
pidranbp2pathwaySumoylation by RanBP2 regulates transcriptional repression
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
netpathPathway_AndrogenReceptorAndrogenReceptor
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1742TP53 Network
wikipathwaysWP179Cell Cycle
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3807Regulation of TP53 Expression and Degradation
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP465Tryptophan metabolism
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD499PDMP1
iGMDRD352PD-03259011
iGMDRD536PLX-47201
iGMDRD85Ursolic acid1
iGMDRD341Triacsin c3
iGMDRD512nutlin 31
iGMDRD84Lovastatin acid5
iGMDRD79Gemcitabine2
iGMDRD720844499-71-41
iGMDRD702SAR4058381
iGMDRD160Cis-Platin3
iGMDRD299ICL 6701
iGMDRD886Compound 1541A5
iGMDRD615BRD-K022519321
iGMDRD5Tyrphostin AG 14782
iGMDRD121GMX17783
iGMDRD271Brefeldin A2
iGMDRD103SN-382
iGMDRD213SMR0000686502
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside5
iGMDRD201SKI II1
iGMDRD446LY 21832402
iGMDRD634SCHEMBL26080412
iGMDRD198AC1LE7KD1
iGMDRD136Nutlin-31
iGMDRD97Bexarotene1
iGMDRD483SCH-5290742
iGMDRD546BMS-7548072
iGMDRD779PRL-3 Inhibitor I3
iGMDRD398Sepantronium2
iGMDRD789DS-3032B1
iGMDRD562Navitoclax1
iGMDRD887Compound 23 citrate1
iGMDRD399Selumetinib1
iGMDRD100Zebularine7
iGMDRD939MDM2 inhibitor (tumors TP53 wt)2
iGMDRD356PNU-746541
iGMDRD23Gossypol2
iGMDRD190Nilotinib1
iGMDRD260FQI-22
iGMDRD474Avrainvillamide2
iGMDRD30917AAG1
iGMDRD390MDM2 inhibitor2
iGMDRD318PAC-11
iGMDRD441TW 371
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MDM2

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