P4HB
Summary: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prolyl 4-hydroxylase subunit beta | MIM:176790 | Ensembl:ENSG00000185624 | HGNC:HGNC:8548 | PA32876 | 17q25.3 |
GO terms in P4HB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006457 | protein folding |
| BP | IDA | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
| BP | TAS | GO:0034378 | chylomicron assembly |
| BP | TAS | GO:0034379 | very-low-density lipoprotein particle assembly |
| BP | IBA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IMP | GO:0034976 | response to endoplasmic reticulum stress |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | TAS | GO:0038155 | interleukin-23-mediated signaling pathway |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IMP | GO:0046598 | positive regulation of viral entry into host cell |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IMP | GO:0071456 | cellular response to hypoxia |
| BP | IBA | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| BP | IMP | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0016222 | procollagen-proline 4-dioxygenase complex |
| CC | IEA | GO:0034663 | endoplasmic reticulum chaperone complex |
| CC | IEA | GO:0042470 | melanosome |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | EXP | GO:0003756 | protein disulfide isomerase activity |
| MF | IBA | GO:0003756 | protein disulfide isomerase activity |
| MF | IDA | GO:0003756 | protein disulfide isomerase activity |
| MF | IDA | GO:0004656 | procollagen-proline 4-dioxygenase activity |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015037 | peptide disulfide oxidoreductase activity |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IBA | GO:0031545 | peptidyl-proline 4-dioxygenase activity |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: P4HB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in P4HB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1650814 | Collagen biosynthesis and modifying enzymes |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5358346 | Hedgehog ligand biogenesis |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8866423 | VLDL assembly |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-8963888 | Chylomicron assembly |
| reactome | R-HSA-8963898 | Plasma lipoprotein assembly |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-9020933 | Interleukin-23 signaling |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 5 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD103 | SN-38 | 8 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 10 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD330 | BRD4132 | 4 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in P4HB
CLASSFICATION
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