P4HB


Summary: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].

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Ensembl ID
HGNC ID
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GO terms in P4HB


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006457 protein folding
BP IDA GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
BP TAS GO:0034378 chylomicron assembly
BP TAS GO:0034379 very-low-density lipoprotein particle assembly
BP IBA GO:0034976 response to endoplasmic reticulum stress
BP IMP GO:0034976 response to endoplasmic reticulum stress
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Gene expression in normal tissue: P4HB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in P4HB


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Database
Pathway ID
Pathway Des.
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1474290 Collagen formation
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1650814 Collagen biosynthesis and modifying enzymes
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 5
iGMDRD138 PX 12 5
iGMDRD52 Rotenone 2
iGMDRD870 BRD63610 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in P4HB

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Model
Level
Reference ID
Tissue
Cancer
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No matching records found

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