PRKCG


Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase C gammaMIM:176980Ensembl:ENSG00000126583HGNC:HGNC:9402PA3376619q13.42

GO terms in PRKCG


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004697protein kinase C activity
MFTASGO:0004698calcium-dependent protein kinase C activity
MFIDAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIEAGO:0005524ATP binding
MFIEAGO:0008270zinc ion binding
CCIEAGO:0005634nucleus
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCISSGO:0005886plasma membrane
CCIEAGO:0005911cell-cell junction
CCIEAGO:0014069postsynaptic density
CCISSGO:0030425dendrite
CCISSGO:0048471perinuclear region of cytoplasm
CCIEAGO:0097060synaptic membrane
BPTASGO:0006468protein phosphorylation
BPIEAGO:0007268chemical synaptic transmission
BPIEAGO:0007611learning or memory
BPIEAGO:0007635chemosensory behavior
BPIDAGO:0016310phosphorylation
BPIBAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0030168platelet activation
BPIDAGO:0031397negative regulation of protein ubiquitination
BPISSGO:0032095regulation of response to food
BPIDAGO:0032425positive regulation of mismatch repair
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0042177negative regulation of protein catabolic process
BPISSGO:0042752regulation of circadian rhythm
BPISSGO:0043278response to morphine
BPISSGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0046777protein autophosphorylation
BPISSGO:0048265response to pain
BPIEAGO:0048511rhythmic process
BPIEAGO:0050764regulation of phagocytosis
BPIEAGO:0060384innervation
BPISSGO:1901799negative regulation of proteasomal protein catabolic process
BPIEAGO:1990911response to psychosocial stress

Gene expression in normal tissue: PRKCG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCG


DatabasePathway IDPathway Des.
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP306Focal Adhesion
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4223Ras Signaling
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
pidendothelinpathwayEndothelins
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
netpathPathway_WntWnt
biocartakeratinocytepathwaykeratinocyte differentiation
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-114516Disinhibition of SNARE formation
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-5099900WNT5A-dependent internalization of FZD4
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD116CD4373
iGMDRD652UNC06383
iGMDRD307Manumycin A2
iGMDRD486Tosedostat4
iGMDRD512nutlin 33
iGMDRD945ML2144
iGMDRD698Neratinib4
iGMDRD221Tamoxifen7
iGMDRD289Parthenolide5
iGMDRD6AM-5802
iGMDRD77Itraconazole3
iGMDRD231Importazole2
iGMDRD267Oligomycin A2
iGMDRD121GMX17786
iGMDRD251ML1622
iGMDRD271Brefeldin A2
iGMDRD202Curcumin8
iGMDRD5Tyrphostin AG 14784
iGMDRD263AACOCF34
iGMDRD552AZD-17755
iGMDRD82Quiflapon2
iGMDRD67PENFLURIDOL4
iGMDRD414MST-3122
iGMDRD662JQ-13
iGMDRD329Merck603
iGMDRD144NSC953972
iGMDRD781Sirolimus2
iGMDRD76Simvastatin2
iGMDRD889Compound 7d-cis3
iGMDRD466Chaetocin1
iGMDRD634SCHEMBL26080413
iGMDRD152179324-69-74
iGMDRD318PAC-12
iGMDRD138PX 125
iGMDRD513BML-2594
iGMDRD399Selumetinib2
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine3
iGMDRD562Navitoclax2
iGMDRD577BIX012945
iGMDRD506Fedratinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCG

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