TNFAIP3
Summary: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF alpha induced protein 3 | MIM:191163 | Ensembl:ENSG00000118503 | HGNC:HGNC:11896 | PA36593 | 6q23.3 |
GO terms in TNFAIP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001922 | B-1 B cell homeostasis |
| BP | IDA | GO:0002237 | response to molecule of bacterial origin |
| BP | ISS | GO:0002634 | regulation of germinal center formation |
| BP | IEA | GO:0002677 | negative regulation of chronic inflammatory response |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IBA | GO:0016477 | cell migration |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IBA | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0032480 | negative regulation of type I interferon production |
| BP | IEA | GO:0032495 | response to muramyl dipeptide |
| BP | IEA | GO:0032691 | negative regulation of interleukin-1 beta production |
| BP | IMP | GO:0032703 | negative regulation of interleukin-2 production |
| BP | ISS | GO:0032715 | negative regulation of interleukin-6 production |
| BP | ISS | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | NAS | GO:0034136 | negative regulation of toll-like receptor 2 signaling pathway |
| BP | IDA | GO:0034140 | negative regulation of toll-like receptor 3 signaling pathway |
| BP | NAS | GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway |
| BP | IEA | GO:0034148 | negative regulation of toll-like receptor 5 signaling pathway |
| BP | IBA | GO:0035523 | protein K29-linked deubiquitination |
| BP | IDA | GO:0035871 | protein K11-linked deubiquitination |
| BP | IDA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0045732 | positive regulation of protein catabolic process |
| BP | IEA | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | NAS | GO:0045779 | negative regulation of bone resorption |
| BP | ISS | GO:0045824 | negative regulation of innate immune response |
| BP | IDA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | NAS | GO:0050691 | regulation of defense response to virus by host |
| BP | ISS | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:0050869 | negative regulation of B cell activation |
| BP | NAS | GO:0051259 | protein complex oligomerization |
| BP | NAS | GO:0061043 | regulation of vascular wound healing |
| BP | ISS | GO:0070301 | cellular response to hydrogen peroxide |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IEA | GO:0070429 | negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway |
| BP | IEA | GO:0070433 | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| BP | IDA | GO:0070536 | protein K63-linked deubiquitination |
| BP | IDA | GO:0070936 | protein K48-linked ubiquitination |
| BP | IDA | GO:0071108 | protein K48-linked deubiquitination |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IBA | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0072573 | tolerance induction to lipopolysaccharide |
| BP | IEA | GO:0072666 | establishment of protein localization to vacuole |
| BP | NAS | GO:0090291 | negative regulation of osteoclast proliferation |
| BP | IDA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:1903364 | positive regulation of cellular protein catabolic process |
| BP | IBA | GO:1990168 | protein K33-linked deubiquitination |
| BP | IEA | GO:2000347 | positive regulation of hepatocyte proliferation |
| BP | IMP | GO:2000349 | negative regulation of CD40 signaling pathway |
| BP | IDA | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005764 | lysosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0002020 | protease binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IBA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | TAS | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0019900 | kinase binding |
| MF | IMP | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043130 | ubiquitin binding |
| MF | IDA | GO:0043621 | protein self-association |
| MF | EXP | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | TAS | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | IBA | GO:0070530 | K63-linked polyubiquitin modification-dependent protein binding |
Gene expression in normal tissue: TNFAIP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFAIP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cd40pathway | cd40l signaling pathway |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5357786 | TNFR1-induced proapoptotic signaling |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD201 | SKI II | 4 |
| iGMDRD359 | OSW-1 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD369 | TGX-115 | 4 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD481 | Dactolisib | 6 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFAIP3
CLASSFICATION
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