BMP4


Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
bone morphogenetic protein 4MIM:112262Ensembl:ENSG00000125378HGNC:HGNC:1071PA2538114q22.2

GO terms in BMP4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFIBAGO:0005160transforming growth factor beta receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIEAGO:0008201heparin binding
MFIPIGO:0039706co-receptor binding
MFIDAGO:0042056chemoattractant activity
MFIBAGO:0070700BMP receptor binding
MFIDAGO:0070700BMP receptor binding
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000186activation of MAPKK activity
BPIDAGO:0001649osteoblast differentiation
BPIDAGO:0001657ureteric bud development
BPIDAGO:0001658branching involved in ureteric bud morphogenesis
BPIMPGO:0001822kidney development
BPIEPGO:0001823mesonephros development
BPIEAGO:0001843neural tube closure
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0001938positive regulation of endothelial cell proliferation
BPISSGO:0001958endochondral ossification
BPIDAGO:0002043blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPISSGO:0002062chondrocyte differentiation
BPIDAGO:0002244hematopoietic progenitor cell differentiation
BPIMPGO:0002320lymphoid progenitor cell differentiation
BPIEAGO:0003014renal system process
BPIMPGO:0003130BMP signaling pathway involved in heart induction
BPIMPGO:0003139secondary heart field specification
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003149membranous septum morphogenesis
BPISSGO:0003150muscular septum morphogenesis
BPISSGO:0003180aortic valve morphogenesis
BPISSGO:0003184pulmonary valve morphogenesis
BPISSGO:0003197endocardial cushion development
BPISSGO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation
BPISSGO:0003215cardiac right ventricle morphogenesis
BPISSGO:0003277apoptotic process involved in endocardial cushion morphogenesis
BPTASGO:0003279cardiac septum development
BPIDAGO:0003323type B pancreatic cell development
BPIDAGO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIDAGO:0007182common-partner SMAD protein phosphorylation
BPIEPGO:0007224smoothened signaling pathway
BPIEAGO:0007281germ cell development
BPIEAGO:0007492endoderm development
BPIEAGO:0007500mesodermal cell fate determination
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0009791post-embryonic development
BPIEAGO:0009948anterior/posterior axis specification
BPIEAGO:0010159specification of animal organ position
BPIDAGO:0010453regulation of cell fate commitment
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPIEAGO:0010718positive regulation of epithelial to mesenchymal transition
BPIBAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIMPGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010942positive regulation of cell death
BPIDAGO:0021537telencephalon development
BPIEAGO:0021904dorsal/ventral neural tube patterning
BPIEAGO:0021978telencephalon regionalization
BPIEAGO:0021983pituitary gland development
BPIEAGO:0030218erythrocyte differentiation
BPIDAGO:0030224monocyte differentiation
BPIDAGO:0030225macrophage differentiation
BPIDAGO:0030501positive regulation of bone mineralization
BPIBAGO:0030509BMP signaling pathway
BPIDAGO:0030509BMP signaling pathway
BPIMPGO:0030509BMP signaling pathway
BPISSGO:0030513positive regulation of BMP signaling pathway
BPIDAGO:0032092positive regulation of protein binding
BPIEAGO:0032331negative regulation of chondrocyte differentiation
BPIDAGO:0032967positive regulation of collagen biosynthetic process
BPIMPGO:0033085negative regulation of T cell differentiation in thymus
BPIMPGO:0033088negative regulation of immature T cell proliferation in thymus
BPIDAGO:0034504protein localization to nucleus
BPIEAGO:0035116embryonic hindlimb morphogenesis
BPISSGO:0035990tendon cell differentiation
BPISSGO:0035993deltoid tuberosity development
BPIDAGO:0042306regulation of protein import into nucleus
BPIDAGO:0042326negative regulation of phosphorylation
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIGIGO:0042476odontogenesis
BPIEAGO:0042487regulation of odontogenesis of dentin-containing tooth
BPIEAGO:0042733embryonic digit morphogenesis
BPIBAGO:0042981regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIMPGO:0043401steroid hormone mediated signaling pathway
BPIDAGO:0043407negative regulation of MAP kinase activity
BPIBAGO:0043408regulation of MAPK cascade
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0045603positive regulation of endothelial cell differentiation
BPIDAGO:0045606positive regulation of epidermal cell differentiation
BPIDAGO:0045662negative regulation of myoblast differentiation
BPIEAGO:0045666positive regulation of neuron differentiation
BPIDAGO:0045669positive regulation of osteoblast differentiation
BPIDAGO:0045778positive regulation of ossification
BPIDAGO:0045786negative regulation of cell cycle
BPIDAGO:0045839negative regulation of mitotic nuclear division
BPIDAGO:0045843negative regulation of striated muscle tissue development
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0048286lung alveolus development
BPIDAGO:0048392intermediate mesodermal cell differentiation
BPIBAGO:0048468cell development
BPIDAGO:0048661positive regulation of smooth muscle cell proliferation
BPIEAGO:0048663neuron fate commitment
BPIEAGO:0048701embryonic cranial skeleton morphogenesis
BPISSGO:0048745smooth muscle tissue development
BPIDAGO:0048754branching morphogenesis of an epithelial tube
BPIDAGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0050680negative regulation of epithelial cell proliferation
BPIEAGO:0050918positive chemotaxis
BPIEAGO:0051150regulation of smooth muscle cell differentiation
BPIEAGO:0055007cardiac muscle cell differentiation
BPIMPGO:0055020positive regulation of cardiac muscle fiber development
BPIEAGO:0060113inner ear receptor cell differentiation
BPIEAGO:0060197cloacal septation
BPIEAGO:0060235lens induction in camera-type eye
BPIEAGO:0060272embryonic skeletal joint morphogenesis
BPIEAGO:0060363cranial suture morphogenesis
BPIDAGO:0060391positive regulation of SMAD protein signal transduction
BPIDAGO:0060393regulation of pathway-restricted SMAD protein phosphorylation
BPIBAGO:0060395SMAD protein signal transduction
BPIDAGO:0060395SMAD protein signal transduction
BPIDAGO:0060425lung morphogenesis
BPIDAGO:0060433bronchus development
BPIDAGO:0060438trachea development
BPIEAGO:0060440trachea formation
BPIDAGO:0060441epithelial tube branching involved in lung morphogenesis
BPIEAGO:0060442branching involved in prostate gland morphogenesis
BPIEAGO:0060449bud elongation involved in lung branching
BPIDAGO:0060502epithelial cell proliferation involved in lung morphogenesis
BPIDAGO:0060503bud dilation involved in lung branching
BPIDAGO:0060548negative regulation of cell death
BPIEAGO:0060592mammary gland formation
BPIEAGO:0060684epithelial-mesenchymal cell signaling
BPIEAGO:0060686negative regulation of prostatic bud formation
BPIEAGO:0060687regulation of branching involved in prostate gland morphogenesis
BPISSGO:0060976coronary vasculature development
BPIDAGO:0061036positive regulation of cartilage development
BPISSGO:0061047positive regulation of branching involved in lung morphogenesis
BPISSGO:0061149BMP signaling pathway involved in ureter morphogenesis
BPISSGO:0061151BMP signaling pathway involved in renal system segmentation
BPIDAGO:0061155pulmonary artery endothelial tube morphogenesis
BPISSGO:0061312BMP signaling pathway involved in heart development
BPISSGO:0061626pharyngeal arch artery morphogenesis
BPIMPGO:0070244negative regulation of thymocyte apoptotic process
BPIEAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0071773cellular response to BMP stimulus
BPIDAGO:0071893BMP signaling pathway involved in nephric duct formation
BPIEPGO:0072001renal system development
BPIEAGO:0072015glomerular visceral epithelial cell development
BPIDAGO:0072097negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
BPIDAGO:0072101specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
BPISSGO:0072104glomerular capillary formation
BPIDAGO:0072125negative regulation of glomerular mesangial cell proliferation
BPIEAGO:0072138mesenchymal cell proliferation involved in ureteric bud development
BPIEAGO:0072161mesenchymal cell differentiation involved in kidney development
BPISSGO:0072192ureter epithelial cell differentiation
BPISSGO:0072193ureter smooth muscle cell differentiation
BPIEAGO:0072198mesenchymal cell proliferation involved in ureter development
BPIDAGO:0072200negative regulation of mesenchymal cell proliferation involved in ureter development
BPISSGO:0072205metanephric collecting duct development
BPIDAGO:0090184positive regulation of kidney development
BPIDAGO:0090191negative regulation of branching involved in ureteric bud morphogenesis
BPIDAGO:0090194negative regulation of glomerulus development
BPISSGO:1901964positive regulation of cell proliferation involved in outflow tract morphogenesis
BPIMPGO:1902893regulation of pri-miRNA transcription by RNA polymerase II
BPIDAGO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II
BPIDAGO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA
BPISSGO:1905072cardiac jelly development
BPIEAGO:1905312positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
BPIDAGO:2000005negative regulation of metanephric S-shaped body morphogenesis
BPIDAGO:2000007negative regulation of metanephric comma-shaped body morphogenesis
BPIMPGO:2000137negative regulation of cell proliferation involved in heart morphogenesis
BPISSGO:2001237negative regulation of extrinsic apoptotic signaling pathway
CCISSGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCISSGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen

Gene expression in normal tissue: BMP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BMP4


DatabasePathway IDPathway Des.
wikipathwaysWP1591Heart Development
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP236Adipogenesis
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP2895Differentiation of white and brown adipocyte
wikipathwaysWP3927BMP Signaling Pathway in Eyelid Development
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP560TGF-beta Receptor Signaling
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidbmppathwayBMP receptor signaling
biocartaalkpathwayalk in cardiac myocytes
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8957275Post-translational protein phosphorylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD237ABT-7513
iGMDRD219Bax channel blocker3
iGMDRD351GW843682X3
iGMDRD945ML2143
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD84Lovastatin acid5
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 36
iGMDRD607Ubistatin B1
iGMDRD532Olaparib3
iGMDRD79Gemcitabine3
iGMDRD286Nsc 6328395
iGMDRD147Prima-11
iGMDRD300Tozasertib8
iGMDRD505Pevonedistat1
iGMDRD121GMX17782
iGMDRD137Indisulam3
iGMDRD103SN-383
iGMDRD5Tyrphostin AG 14782
iGMDRD6AM-5801
iGMDRD107Valdecoxib3
iGMDRD71Sparfosic acid2
iGMDRD446LY 21832403
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-72
iGMDRD466Chaetocin2
iGMDRD375GW-4058333
iGMDRD210AC556491
iGMDRD554CHEMBL14341373
iGMDRD126Tipifarnib5
iGMDRD420Leucascandrolide A2
iGMDRD772BRD47702
iGMDRD579PF7502
iGMDRD779PRL-3 Inhibitor I3
iGMDRD546BMS-7548072
iGMDRD781Sirolimus5
iGMDRD494Neopeltolide3
iGMDRD483SCH-5290743
iGMDRD887Compound 23 citrate4
iGMDRD188Piperlongumine3
iGMDRD398Sepantronium2
iGMDRD506Fedratinib2
iGMDRD369TGX-1155
iGMDRD64Parbendazole3
iGMDRD23Gossypol3
iGMDRD356PNU-746543
iGMDRD870BRD636105
iGMDRD441TW 371
iGMDRD318PAC-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BMP4

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