CHD6


Summary: This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
chromodomain helicase DNA binding protein 6MIM:616114Ensembl:ENSG00000124177HGNC:HGNC:19057PA13497470020q12

GO terms in CHD6


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001221transcription cofactor binding
MFIEAGO:0003677DNA binding
MFIEAGO:0004386helicase activity
MFIEAGO:0005524ATP binding
MFIDAGO:0008094DNA-dependent ATPase activity
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005665DNA-directed RNA polymerase II, core complex
BPIEAGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0016032viral process
BPIMPGO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Gene expression in normal tissue: CHD6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHD6


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD248BRD43541
iGMDRD584VER 1550082
iGMDRD150RITA5
iGMDRD57Chloropentafluorobenzene3
iGMDRD341Triacsin c3
iGMDRD211(1S,3R)-RSL32
iGMDRD251ML1622
iGMDRD137Indisulam3
iGMDRD271Brefeldin A4
iGMDRD434BMS-5369243
iGMDRD105Triptolide2
iGMDRD289Parthenolide7
iGMDRD286Nsc 6328395
iGMDRD505Pevonedistat8
iGMDRD889Compound 7d-cis3
iGMDRD126Tipifarnib3
iGMDRD462OSI-906 (Linsitinib)2
iGMDRD494Neopeltolide2
iGMDRD670ML 2101
iGMDRD144NSC953972
iGMDRD546BMS-7548071
iGMDRD427ABT7374
iGMDRD193Fqi12
iGMDRD61Kinetin riboside1
iGMDRD639YK 4-2793
iGMDRD634SCHEMBL26080412
iGMDRD679Bistramide A2
iGMDRD394BX-7953
iGMDRD255SB2250021
iGMDRD474Avrainvillamide1
iGMDRD138PX 123
iGMDRD870BRD636104
iGMDRD441TW 371
iGMDRD318PAC-12
iGMDRD780PP-302
iGMDRD577BIX012942
iGMDRD506Fedratinib6
iGMDRD188Piperlongumine6
iGMDRD444Tivantinib3
iGMDRD64Parbendazole2
iGMDRD690PRIMA-1MET2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHD6

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