STAT5A
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| signal transducer and activator of transcription 5A | MIM:601511 | Ensembl:ENSG00000126561 | HGNC:HGNC:11366 | PA338 | 17q21.2 |
GO terms in STAT5A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | ISS | GO:0000255 | allantoin metabolic process |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | ISS | GO:0006101 | citrate metabolic process |
| BP | ISS | GO:0006103 | 2-oxoglutarate metabolic process |
| BP | ISS | GO:0006105 | succinate metabolic process |
| BP | ISS | GO:0006107 | oxaloacetate metabolic process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0006549 | isoleucine metabolic process |
| BP | ISS | GO:0006573 | valine metabolic process |
| BP | ISS | GO:0006600 | creatine metabolic process |
| BP | ISS | GO:0006631 | fatty acid metabolic process |
| BP | TAS | GO:0007259 | JAK-STAT cascade |
| BP | IEA | GO:0007595 | lactation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | ISS | GO:0019530 | taurine metabolic process |
| BP | TAS | GO:0035723 | interleukin-15-mediated signaling pathway |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | TAS | GO:0038111 | interleukin-7-mediated signaling pathway |
| BP | ISS | GO:0040014 | regulation of multicellular organism growth |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | ISS | GO:0046449 | creatinine metabolic process |
| BP | TAS | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway |
Gene expression in normal tissue: STAT5A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAT5A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1170546 | Prolactin receptor signaling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-8985947 | Interleukin-9 signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-9020958 | Interleukin-21 signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | epopathway | epo signaling pathway |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il3pathway | il 3 signaling pathway |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | tpopathway | tpo signaling pathway |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epopathway | EPO signaling pathway |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_IL9 | IL9 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3945 | TYROBP Causal Network |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP673 | ErbB Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 8 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD150 | RITA | 5 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD505 | Pevonedistat | 11 |
| iGMDRD246 | NPC26 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAT5A
CLASSFICATION
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