TEX14
Summary: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| testis expressed 14, intercellular bridge forming factor | MIM:605792 | Ensembl:ENSG00000121101 | HGNC:HGNC:11737 | PA36454 | 17q22 |
GO terms in TEX14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | ISS | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | IBA | GO:0007140 | male meiotic nuclear division |
| BP | ISS | GO:0007140 | male meiotic nuclear division |
| BP | IBA | GO:0008608 | attachment of spindle microtubules to kinetochore |
| BP | ISS | GO:0008608 | attachment of spindle microtubules to kinetochore |
| BP | IEA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0032466 | negative regulation of cytokinesis |
| BP | IBA | GO:0043063 | intercellular bridge organization |
| BP | ISS | GO:0043063 | intercellular bridge organization |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0051306 | mitotic sister chromatid separation |
| BP | ISS | GO:0051306 | mitotic sister chromatid separation |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | IBA | GO:0000776 | kinetochore |
| CC | ISS | GO:0000776 | kinetochore |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | ISS | GO:0005623 | cell |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0030496 | midbody |
| CC | ISS | GO:0030496 | midbody |
| CC | IBA | GO:0045171 | intercellular bridge |
| CC | ISS | GO:0045171 | intercellular bridge |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: TEX14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TEX14
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD322 | FK 866 | 4 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD441 | TW 37 | 5 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD546 | BMS-754807 | 5 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD126 | Tipifarnib | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TEX14
CLASSFICATION
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