ZMYM2
Summary: The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger MYM-type containing 2 | MIM:602221 | Ensembl:ENSG00000121741 | HGNC:HGNC:12989 | PA37569 | 13q12.11 |
GO terms in ZMYM2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0031624 | ubiquitin conjugating enzyme binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0022604 | regulation of cell morphogenesis |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
Gene expression in normal tissue: ZMYM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZMYM2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD226 | ML006 | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD690 | PRIMA-1MET | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD237 | ABT-751 | 7 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD414 | MST-312 | 7 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZMYM2
CLASSFICATION
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