ZMYM2
Summary: The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
zinc finger MYM-type containing 2 | MIM:602221 | Ensembl:ENSG00000121741 | HGNC:HGNC:12989 | PA37569 | 13q12.11 |
GO terms in ZMYM2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | TAS | GO:0004713 | protein tyrosine kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | NAS | GO:0008270 | zinc ion binding |
MF | IPI | GO:0031624 | ubiquitin conjugating enzyme binding |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IBA | GO:0007010 | cytoskeleton organization |
BP | ND | GO:0008150 | biological_process |
BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
BP | IBA | GO:0022604 | regulation of cell morphogenesis |
CC | IBA | GO:0005654 | nucleoplasm |
CC | IBA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0016605 | PML body |
Gene expression in normal tissue: ZMYM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZMYM2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1226099 | Signaling by FGFR in disease |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD889 | Compound 7d-cis | 2 |
iGMDRD781 | Sirolimus | 2 |
iGMDRD61 | Kinetin riboside | 2 |
iGMDRD193 | Fqi1 | 1 |
iGMDRD446 | LY 2183240 | 4 |
iGMDRD634 | SCHEMBL2608041 | 2 |
iGMDRD280 | CYTOCHALASIN B | 5 |
iGMDRD297 | Austocystin D | 2 |
iGMDRD260 | FQI-2 | 1 |
iGMDRD255 | SB225002 | 4 |
iGMDRD870 | BRD63610 | 1 |
iGMDRD226 | ML006 | 1 |
iGMDRD562 | Navitoclax | 2 |
iGMDRD888 | Compound 44 | 3 |
iGMDRD188 | Piperlongumine | 6 |
iGMDRD23 | Gossypol | 3 |
iGMDRD64 | Parbendazole | 4 |
iGMDRD690 | PRIMA-1MET | 1 |
iGMDRD512 | nutlin 3 | 1 |
iGMDRD307 | Manumycin A | 2 |
iGMDRD48 | Dexamethasone | 2 |
iGMDRD424 | Tamatinib | 2 |
iGMDRD560 | MK-2206 | 2 |
iGMDRD237 | ABT-751 | 7 |
iGMDRD351 | GW843682X | 1 |
iGMDRD85 | Ursolic acid | 1 |
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
iGMDRD154 | NSC23766 | 3 |
iGMDRD123 | Isoevodiamine | 5 |
iGMDRD137 | Indisulam | 1 |
iGMDRD271 | Brefeldin A | 2 |
iGMDRD121 | GMX1778 | 2 |
iGMDRD103 | SN-38 | 1 |
iGMDRD77 | Itraconazole | 1 |
iGMDRD105 | Triptolide | 6 |
iGMDRD6 | AM-580 | 2 |
iGMDRD221 | Tamoxifen | 2 |
iGMDRD705 | Nakiterpiosin | 4 |
iGMDRD67 | PENFLURIDOL | 4 |
iGMDRD414 | MST-312 | 7 |
iGMDRD367 | Ro 28-1675 | 2 |
iGMDRD286 | Nsc 632839 | 5 |
iGMDRD246 | NPC26 | 3 |
iGMDRD886 | Compound 1541A | 2 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ZMYM2