CCND1
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin D1 | MIM:168461 | Ensembl:ENSG00000110092 | HGNC:HGNC:1582 | PA75 | 11q13.3 |
GO terms in CCND1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IEA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IDA | GO:0070064 | proline-rich region binding |
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IDA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0000320 | re-entry into mitotic cell cycle |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEA | GO:0007595 | lactation |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010039 | response to iron ion |
| BP | IEA | GO:0010165 | response to X-ray |
| BP | IEA | GO:0010243 | response to organonitrogen compound |
| BP | IDA | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IEA | GO:0030857 | negative regulation of epithelial cell differentiation |
| BP | IEA | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | IDA | GO:0031571 | mitotic G1 DNA damage checkpoint |
| BP | IEA | GO:0032026 | response to magnesium ion |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0033197 | response to vitamin E |
| BP | IEA | GO:0033327 | Leydig cell differentiation |
| BP | IEA | GO:0033598 | mammary gland epithelial cell proliferation |
| BP | IEA | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation |
| BP | IEP | GO:0042493 | response to drug |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IDA | GO:0044321 | response to leptin |
| BP | IEA | GO:0045444 | fat cell differentiation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IDA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0045787 | positive regulation of cell cycle |
| BP | TAS | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051412 | response to corticosterone |
| BP | IEA | GO:0051592 | response to calcium ion |
| BP | IEA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IEA | GO:0060749 | mammary gland alveolus development |
| BP | IDA | GO:0070141 | response to UV-A |
| BP | IDA | GO:0071157 | negative regulation of cell cycle arrest |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IBA | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0005622 | intracellular |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005923 | bicellular tight junction |
| CC | IEA | GO:0016020 | membrane |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
Gene expression in normal tissue: CCND1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCND1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | notch_pathway | Notch signaling pathway |
| pid | p38gammadeltapathway | Signaling mediated by p38-gamma and p38-delta |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_Wnt | Wnt |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2878 | PPAR Alpha Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3969 | H19 action Rb-E2F1 signaling and CDK-?-catenin activity |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4107 | Transcriptional regulation by RUNX3 |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP61 | Notch Signaling Pathway |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP707 | DNA Damage Response |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69229 | Ubiquitin-dependent degradation of Cyclin D1 |
| reactome | R-HSA-69229 | Ubiquitin-dependent degradation of Cyclin D1 |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D |
| reactome | R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849470 | PTK6 Regulates Cell Cycle |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8951430 | RUNX3 regulates WNT signaling |
| reactome | R-HSA-8951936 | RUNX3 regulates p14-ARF |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| biocarta | btg2pathway | btg family proteins and cell cycle regulation |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | p53pathway | p53 signaling pathway |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD317 | CCT 018159 | 1 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD200 | STF62247 | 1 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD1006 | SMO inhibitor | 1 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD288 | Carboplatin | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD183 | CDK4/6 inhibitor | 4 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD131 | Erlotinib | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD133 | Lapatinib | 2 |
| iGMDRD312 | Pelitinib | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD440 | Nutlin-3A | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD284 | Palbociclib | 6 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD134 | Sorafenib | 2 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD474 | Avrainvillamide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCND1
CLASSFICATION
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