CYP2B6
Summary: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:123930 Ensembl IDEnsembl:ENSG00000197408 HGNC IDHGNC:HGNC:2615 PHARMGKB IDPA123 Map Location19q13.2 | |||||
GO terms in CYP2B6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004497 | monooxygenase activity |
| MF | TAS | GO:0004497 | monooxygenase activity |
| MF | IEA | GO:0005506 | iron ion binding |
| MF | IBA | GO:0008392 | arachidonic acid epoxygenase activity |
| MF | IBA | GO:0008395 | steroid hydroxylase activity |
| MF | IBA | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Gene expression in normal tissue: CYP2B6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP2B6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1600 | Nicotine Metabolism |
| wikipathways | WP2874 | Liver X Receptor Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP2B6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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