CYP2B6


Summary: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].

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GO terms in CYP2B6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004497 monooxygenase activity
MF TAS GO:0004497 monooxygenase activity
MF IEA GO:0005506 iron ion binding
MF IBA GO:0008392 arachidonic acid epoxygenase activity
MF IBA GO:0008395 steroid hydroxylase activity
MF IBA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
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Gene expression in normal tissue: CYP2B6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP2B6


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Database
Pathway ID
Pathway Des.
wikipathways WP1600 Nicotine Metabolism
wikipathways WP2874 Liver X Receptor Pathway
wikipathways WP2875 Constitutive Androstane Receptor Pathway
wikipathways WP2876 Pregnane X Receptor pathway
wikipathways WP2877 Vitamin D Receptor Pathway
wikipathways WP2882 Nuclear Receptors Meta-Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD887 Compound 23 citrate 2
iGMDRD188 Piperlongumine 4
iGMDRD577 BIX01294 5
iGMDRD64 Parbendazole 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP2B6

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Cancer
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