EPHA8


Summary: This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor A8MIM:176945Ensembl:ENSG00000070886HGNC:HGNC:3391PA278231p36.12

GO terms in EPHA8


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0006929substrate-dependent cell migration
BPIEAGO:0007155cell adhesion
BPIBAGO:0007275multicellular organism development
BPISSGO:0007411axon guidance
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0016322neuron remodeling
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPISSGO:0030155regulation of cell adhesion
BPISSGO:0031175neuron projection development
BPISSGO:0033628regulation of cell adhesion mediated by integrin
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0043410positive regulation of MAPK cascade
BPISSGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPISSGO:0046777protein autophosphorylation
BPISSGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071372cellular response to follicle-stimulating hormone stimulus
CCIBAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCIEAGO:0031901early endosome membrane
CCIBAGO:0043005neuron projection
CCISSGO:0043005neuron projection
CCIBAGO:0043235receptor complex
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFISSGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding

Gene expression in normal tissue: EPHA8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA8


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
pidepha_fwdpathwayEPHA forward signaling
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD698Neratinib3
iGMDRD351GW843682X3
iGMDRD945ML2141
iGMDRD123Isoevodiamine1
iGMDRD84Lovastatin acid3
iGMDRD486Tosedostat2
iGMDRD405PIK-752
iGMDRD701NVP-AUY9222
iGMDRD116CD4371
iGMDRD424Tamatinib3
iGMDRD329Merck603
iGMDRD366PI-1034
iGMDRD414MST-3122
iGMDRD286Nsc 6328393
iGMDRD505Pevonedistat3
iGMDRD5Tyrphostin AG 14782
iGMDRD103SN-384
iGMDRD202Curcumin3
iGMDRD481Dactolisib2
iGMDRD267Oligomycin A3
iGMDRD221Tamoxifen1
iGMDRD105Triptolide5
iGMDRD6AM-5802
iGMDRD639YK 4-2792
iGMDRD193Fqi13
iGMDRD446LY 21832401
iGMDRD679Bistramide A3
iGMDRD387CHIR-990214
iGMDRD579PF7501
iGMDRD1008SR-II-138A2
iGMDRD151CHM-11
iGMDRD427ABT7371
iGMDRD546BMS-7548071
iGMDRD144NSC953972
iGMDRD188Piperlongumine3
iGMDRD268Cerulenin2
iGMDRD630ML2033
iGMDRD640CAY106182
iGMDRD64Parbendazole3
iGMDRD255SB2250022
iGMDRD513BML-2592

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA8

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