FGFR1


Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibroblast growth factor receptor 1MIM:136350Ensembl:ENSG00000077782HGNC:HGNC:3688PA281278p11.23

GO terms in FGFR1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005007fibroblast growth factor-activated receptor activity
MFIDAGO:0005007fibroblast growth factor-activated receptor activity
MFTASGO:0005007fibroblast growth factor-activated receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008201heparin binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIBAGO:0017134fibroblast growth factor binding
MFIDAGO:0017134fibroblast growth factor binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIDAGO:0090722receptor-receptor interaction
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0000165MAPK cascade
BPTASGO:0001501skeletal system development
BPIBAGO:0001525angiogenesis
BPIEAGO:0001525angiogenesis
BPIEAGO:0001657ureteric bud development
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001759organ induction
BPTASGO:0001764neuron migration
BPIEAGO:0002053positive regulation of mesenchymal cell proliferation
BPIEAGO:0002062chondrocyte differentiation
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006468protein phosphorylation
BPIBAGO:0007275multicellular organism development
BPIBAGO:0007417central nervous system development
BPIEAGO:0007605sensory perception of sound
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIGIGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIDAGO:0008543fibroblast growth factor receptor signaling pathway
BPIGIGO:0008543fibroblast growth factor receptor signaling pathway
BPIPIGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIBAGO:0009968negative regulation of signal transduction
BPTASGO:0010518positive regulation of phospholipase activity
BPIDAGO:0010863positive regulation of phospholipase C activity
BPIEAGO:0010966regulation of phosphate transport
BPIEAGO:0010976positive regulation of neuron projection development
BPTASGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPTASGO:0016477cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021847ventricular zone neuroblast division
BPIBAGO:0030154cell differentiation
BPIEAGO:0030326embryonic limb morphogenesis
BPIEAGO:0030901midbrain development
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0035607fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0042472inner ear morphogenesis
BPIEAGO:0042473outer ear morphogenesis
BPIEAGO:0042474middle ear morphogenesis
BPTASGO:0043009chordate embryonic development
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIMPGO:0043410positive regulation of MAPK cascade
BPIGIGO:0043536positive regulation of blood vessel endothelial cell migration
BPTASGO:0045595regulation of cell differentiation
BPIMPGO:0045666positive regulation of neuron differentiation
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPIEAGO:0048339paraxial mesoderm development
BPIEAGO:0048378regulation of lateral mesodermal cell fate specification
BPIEAGO:0048469cell maturation
BPTASGO:0048705skeletal system morphogenesis
BPIEAGO:0048762mesenchymal cell differentiation
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060045positive regulation of cardiac muscle cell proliferation
BPIEAGO:0060117auditory receptor cell development
BPIEAGO:0060445branching involved in salivary gland morphogenesis
BPIEAGO:0060484lung-associated mesenchyme development
BPIEAGO:0060665regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0070640vitamin D3 metabolic process
BPIEAGO:0090080positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
BPIEAGO:0090272negative regulation of fibroblast growth factor production
BPIEAGO:1903465positive regulation of mitotic cell cycle DNA replication
BPIGIGO:1905564positive regulation of vascular endothelial cell proliferation
BPIDAGO:2000546positive regulation of endothelial cell chemotaxis to fibroblast growth factor
BPIEAGO:2000830positive regulation of parathyroid hormone secretion
BPIEAGO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCNASGO:0005576extracellular region
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCNASGO:0016021integral component of membrane
CCIEAGO:0031410cytoplasmic vesicle
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex

Gene expression in normal tissue: FGFR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGFR1


DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1839120Signaling by FGFR1 amplification mutants
reactomeR-HSA-1839122Signaling by activated point mutants of FGFR1
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-190242FGFR1 ligand binding and activation
reactomeR-HSA-190370FGFR1b ligand binding and activation
reactomeR-HSA-190373FGFR1c ligand binding and activation
reactomeR-HSA-190374FGFR1c and Klotho ligand binding and activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-5654219Phospholipase C-mediated cascade: FGFR1
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654688SHC-mediated cascade:FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-8853336Signaling by plasma membrane FGFR1 fusions
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP51Regulation of Actin Cytoskeleton
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidfgf_pathwayFGF signaling pathway
pidglypican_1pathwayGlypican 1 network
pidncadherinpathwayN-cadherin signaling events
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidsyndecan_3_pathwaySyndecan-3-mediated signaling events
pidsyndecan_4_pathwaySyndecan-4-mediated signaling events
pharmgkbPA165959425Pathway_PA165959425
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD103SN-386
iGMDRD137Indisulam6
iGMDRD674Dovitinib2
iGMDRD105Triptolide6
iGMDRD705Nakiterpiosin6
iGMDRD481Dactolisib3
iGMDRD691Infigratinib4
iGMDRD551Ponatinib4
iGMDRD286Nsc 6328399
iGMDRD872BRD71373
iGMDRD3PD-1730744
iGMDRD246NPC266
iGMDRD263AACOCF36
iGMDRD512nutlin 33
iGMDRD150RITA1
iGMDRD116CD4373
iGMDRD523Cyanoquinoline, 113
iGMDRD567E-38101
iGMDRD237ABT-7516
iGMDRD123Isoevodiamine3
iGMDRD883CIL55A1
iGMDRD945ML2142
iGMDRD138PX 123
iGMDRD260FQI-23
iGMDRD255SB2250023
iGMDRD1754-Hydroxytamoxifen1
iGMDRD171Pemetrexed3
iGMDRD885Compound 1106
iGMDRD188Piperlongumine6
iGMDRD399Selumetinib3
iGMDRD911FGFR inhibitor7
iGMDRD369TGX-1153
iGMDRD64Parbendazole3
iGMDRD356PNU-746543
iGMDRD524ISX-96
iGMDRD126Tipifarnib3
iGMDRD685AZD45472
iGMDRD151CHM-13
iGMDRD420Leucascandrolide A3
iGMDRD1008SR-II-138A3
iGMDRD779PRL-3 Inhibitor I3
iGMDRD546BMS-7548073
iGMDRD446LY 21832403
iGMDRD466Chaetocin3
iGMDRD634SCHEMBL26080411
iGMDRD359OSW-13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGFR1

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