LCK
Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LCK proto-oncogene, Src family tyrosine kinase | MIM:153390 | Ensembl:ENSG00000182866 | HGNC:HGNC:6524 | PA30307 | 1p35.2 |
GO terms in LCK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | ISS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | ISS | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0042169 | SH2 domain binding |
| MF | ISS | GO:0042169 | SH2 domain binding |
| MF | IPI | GO:0042608 | T cell receptor binding |
| MF | IPI | GO:0042609 | CD4 receptor binding |
| MF | IPI | GO:0042610 | CD8 receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IPI | GO:0051117 | ATPase binding |
| CC | IDA | GO:0000242 | pericentriolar material |
| CC | ISS | GO:0000242 | pericentriolar material |
| CC | IDA | GO:0001772 | immunological synapse |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IDA | GO:0045121 | membrane raft |
| CC | ISS | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006470 | protein dephosphorylation |
| BP | IEP | GO:0006882 | cellular zinc ion homeostasis |
| BP | ISS | GO:0006882 | cellular zinc ion homeostasis |
| BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | ISS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IMP | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | NAS | GO:0030097 | hemopoiesis |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IBA | GO:0030217 | T cell differentiation |
| BP | IMP | GO:0030217 | T cell differentiation |
| BP | ISS | GO:0030217 | T cell differentiation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0042493 | response to drug |
| BP | ISS | GO:0042493 | response to drug |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0050690 | regulation of defense response to virus by virus |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IBA | GO:0050853 | B cell receptor signaling pathway |
| BP | NAS | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| BP | IDA | GO:0050870 | positive regulation of T cell activation |
| BP | ISS | GO:0050870 | positive regulation of T cell activation |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | ISS | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | NAS | GO:0051249 | regulation of lymphocyte activation |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IMP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| BP | ISS | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
Gene expression in normal tissue: LCK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LCK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| reactome | R-HSA-164944 | Nef and signal transduction |
| reactome | R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis |
| reactome | R-HSA-167590 | Nef Mediated CD4 Down-regulation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains |
| reactome | R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse |
| reactome | R-HSA-202433 | Generation of second messenger molecules |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-389359 | CD28 dependent Vav1 pathway |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-389948 | PD-1 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | tcrapathway | lck and fyn tyrosine kinases in initiation of tcr activation |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | glypican_1pathway | Glypican 1 network |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_TCR | TCR |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP453 | Inflammatory Response Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP61 | Notch Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD239 | Dasatinib | 1 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD189 | CGP 60474 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD598 | QS-11 | 1 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD127 | Seliciclib | 1 |
| iGMDRD609 | BRD-K66453893 | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD858 | BRD-K71935468 | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD604 | 4449-51-8 | 1 |
| iGMDRD168 | BMS-270394 | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD389 | SB525334 | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD550 | CGP-082996 | 1 |
| iGMDRD384 | EHT-1864 | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD403 | BAY 61-3606 | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD249 | CCT036477 | 1 |
| iGMDRD778 | SCHEMBL13586708 | 1 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD861 | BRD-K92856060 | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD431 | NU-7441 | 1 |
| iGMDRD225 | AC1MD3YP | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD391 | OSU-03012 | 1 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD1036 | X17AAG | 1 |
| iGMDRD184 | IPA-3 | 1 |
| iGMDRD605 | AZD6482 | 2 |
| iGMDRD49 | Mitomycin | 1 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD311 | Dacinostat | 1 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD442 | BMS-509744 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LCK
CLASSFICATION
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