MYH1


Summary: Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
myosin heavy chain 1MIM:160730Ensembl:ENSG00000109061HGNC:HGNC:7567PA3136517p13.1

GO terms in MYH1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008017microtubule binding
MFIEAGO:0051015actin filament binding
BPIEAGO:0006936muscle contraction
BPIEAGO:0007018microtubule-based movement
CCIDAGO:0005859muscle myosin complex
CCIEAGO:0014704intercalated disc
CCIEAGO:0031672A band
CCIEAGO:0032982myosin filament
CCIDAGO:0036464cytoplasmic ribonucleoprotein granule

Gene expression in normal tissue: MYH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYH1


DatabasePathway IDPathway Des.
kegghsa04530Tight junction - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD870BRD636102
iGMDRD187BRD98761
iGMDRD171Pemetrexed2
iGMDRD782DC-45-A24
iGMDRD255SB2250024
iGMDRD260FQI-21
iGMDRD451Serdemetan2
iGMDRD64Parbendazole4
iGMDRD577BIX012944
iGMDRD399Selumetinib1
iGMDRD188Piperlongumine5
iGMDRD670ML 2102
iGMDRD229B023
iGMDRD151CHM-11
iGMDRD433Lexibulin3
iGMDRD375GW-4058332
iGMDRD634SCHEMBL26080412
iGMDRD280CYTOCHALASIN B1
iGMDRD466Chaetocin2
iGMDRD394BX-7953
iGMDRD193Fqi12
iGMDRD639YK 4-2793
iGMDRD446LY 21832402
iGMDRD231Importazole3
iGMDRD415LE-1352
iGMDRD434BMS-5369244
iGMDRD705Nakiterpiosin3
iGMDRD5Tyrphostin AG 14781
iGMDRD158NSC1415402
iGMDRD137Indisulam1
iGMDRD42Vorinostat4
iGMDRD246NPC262
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A2
iGMDRD329Merck602
iGMDRD872BRD71372
iGMDRD701NVP-AUY9223
iGMDRD79Gemcitabine1
iGMDRD424Tamatinib2
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD560MK-22061
iGMDRD512nutlin 32
iGMDRD154NSC237662
iGMDRD883CIL55A4
iGMDRD435BI-25363
iGMDRD177Teniposide2
iGMDRD123Isoevodiamine4
iGMDRD237ABT-7512

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYH1

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