UBR5


Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin protein ligase E3 component n-recognin 5MIM:608413Ensembl:ENSG00000104517HGNC:HGNC:16806PA1624081758q22.3

GO terms in UBR5


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCHDAGO:0016020membrane
CCIDAGO:0032991protein-containing complex
CCIDAGO:0048471perinuclear region of cytoplasm
BPIBAGO:0000209protein polyubiquitination
BPIDAGO:0000209protein polyubiquitination
BPIEAGO:0006281DNA repair
BPTASGO:0006511ubiquitin-dependent protein catabolic process
BPIBAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0006974cellular response to DNA damage stimulus
BPTASGO:0008283cell proliferation
BPIDAGO:0010628positive regulation of gene expression
BPIMPGO:0033160positive regulation of protein import into nucleus, translocation
BPIDAGO:0050847progesterone receptor signaling pathway
BPIDAGO:0070936protein K48-linked ubiquitination
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPIBAGO:1901315negative regulation of histone H2A K63-linked ubiquitination
BPIMPGO:1901315negative regulation of histone H2A K63-linked ubiquitination
BPIBAGO:2000779regulation of double-strand break repair
BPIMPGO:2000780negative regulation of double-strand break repair
MFIEAGO:0003723RNA binding
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIDAGO:0034450ubiquitin-ubiquitin ligase activity
MFIEAGO:0043130ubiquitin binding
MFIDAGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: UBR5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UBR5


DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP465Tryptophan metabolism
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD451Serdemetan1
iGMDRD23Gossypol3
iGMDRD64Parbendazole1
iGMDRD398Sepantronium6
iGMDRD506Fedratinib3
iGMDRD888Compound 443
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib3
iGMDRD74Idarubicin9
iGMDRD100Zebularine6
iGMDRD188Piperlongumine2
iGMDRD187BRD98763
iGMDRD171Pemetrexed3
iGMDRD782DC-45-A23
iGMDRD613CHEMBL2581481
iGMDRD255SB2250023
iGMDRD260FQI-23
iGMDRD138PX 122
iGMDRD513BML-2593
iGMDRD466Chaetocin1
iGMDRD280CYTOCHALASIN B3
iGMDRD394BX-7953
iGMDRD297Austocystin D2
iGMDRD61Kinetin riboside1
iGMDRD193Fqi13
iGMDRD71Sparfosic acid3
iGMDRD446LY 21832401
iGMDRD599Salermide3
iGMDRD151CHM-16
iGMDRD322FK 8663
iGMDRD366PI-1036
iGMDRD434BMS-5369243
iGMDRD289Parthenolide6
iGMDRD105Triptolide2
iGMDRD705Nakiterpiosin3
iGMDRD5Tyrphostin AG 14783
iGMDRD158NSC1415406
iGMDRD121GMX17784
iGMDRD945ML2141
iGMDRD123Isoevodiamine6
iGMDRD177Teniposide3
iGMDRD237ABT-7513
iGMDRD351GW843682X6
iGMDRD85Ursolic acid3
iGMDRD79Gemcitabine4
iGMDRD424Tamatinib3
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD512nutlin 33
iGMDRD84Lovastatin acid4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBR5

​​​​